糖尿病视网膜病变中视网膜电图振荡电位及尿微量白蛋白水平的分析

目的 研究视网膜电图振荡电位(OPs)总振幅及尿微量白蛋白(U-mAlb)水平在糖尿病视网膜病变(DR)各期中的变化情况,探讨将这些指标应用于临床筛查的可能性. 方法 测定健康对照组、临床前期组及轻、中、重度非增生性DR组和增生性DR组等6组的闪光视网膜电图(FERG)的OPs总振幅及U-mAlb排出量,并行统计学比较. 结果 OPs总振幅及U-mAlb排出量与DR各组间有显著相关性.OPs总振幅随着DR程度的加重而减小,6组间差别均有统计学意义(P<0.01).U-mAlb排出量在健康对照组、临床前期组及轻度非增生性DR组中差别无统计学意义,但在中度非增生性 DR组、重度非增生性 DR组及增生性 DR组中差别有统计学意义(P<0.01),且病变越严重,U-mAlb排出量上升越快. 结论 OPs总振幅可作为DR的定量指标,对诊断有重要价值,尤其是早期DR,敏感性较高;U-mAlb排出量与DR的严重程度相关.

Analysis of Electroretinogram Oscillatory Potentials and Urinary Microalbumin Levels in Diabetic Retinopathy

Objective To investigate the total oscillatory potentials(OPs)amplitude of the elec-troretinogram and Urinarymicroalbumin(U-mAlb)levels in diabetic retinopathy(DR)changes in different phases;to explore the possibility of using these indicators in clinical screening. Methods T he total OPs amplitude of flash electroretinogram(FERG)and U-mAlb output were measured in the following groups:healthy control groups,subclinical DR groups,mild,medium,and severe non-proliferative DR groups and proliferative DR groups.Then the results were statistically analyzed. Results There was a significant correlation between the total amplitude of OPs and the amount of U-mAlb excreted in different DR groups. The total amplitude of OPs decreased with the aggravation of DR,and the differences between the six groups were statistically significant.The differences of U-mAlb excretion among healthy control groups, subclinical DR groups and mild non-proliferative DR groups were not statistically significant,but there were statistical significance among moderate non-proliferative DR groups,severe non-proliferative and pro-liferative DR group,while the U-mAlb emissions increased faster when the lesions were more severe. Conclusions The total amplitude of OPs can be used as a quantitative index for DR with high sensitivity, which is of great value for the diagnosis of DR,especially for early DR.The amount of U-mAlb excreted was related to the severity of DR.OPs is proposed for early DR screening and U-mAlb can be used to de-termine the severity of the disease and prognosis.