| 反相高效液相色谱法测定醋酸甲萘氢醌片的含量 |
| |
| 引用本文： | 林昀,龚士学,程辉跃. 反相高效液相色谱法测定醋酸甲萘氢醌片的含量[J]. 中国药业, 2011, 20(1): 24-25 |
| |
| 作者姓名： | 林昀 龚士学 程辉跃 |
| |
| 作者单位： | 重庆市药品检验所,重庆,401121 |
| |
| 基金项目： | 国家药典委员会2010版药典科研项目 |
| |
| 摘 要： | 目的建立测定醋酸甲萘氢醌片含量的反相高效液相色谱法。方法采用Welch Materials C18色谱柱(150 mm×4.6 mm,5μm),以乙腈-水(65∶35)为流动相,检测波长285 nm,流速1.0 mL/min,进样量20μL。结果醋酸甲萘氢醌质量浓度在4.0～60.0μg/mL范围内与峰面积线性关系良好(r=1.000),平均回收率99.93%,RSD=1.21%(n=9)。结论所用方法简便,重复性好,结果准确可靠,可作为醋酸甲萘氢醌制剂的质量控制方法。
|
| 关 键 词： | 醋酸甲萘氢醌 反相高效液相色谱法 含量测定 |
Content Determination of Menadiol Diacetate Tablets by RP - HPLC |
| |
| Lin Yun,Gong Shixue,Cheng Huiyue. Content Determination of Menadiol Diacetate Tablets by RP - HPLC[J]. China Pharmaceuticals, 2011, 20(1): 24-25 |
| |
| Authors: | Lin Yun Gong Shixue Cheng Huiyue |
| |
| Affiliation: | Lin Yun,Gong Shixue,Cheng Huiyue(Chongqing Institute for Drug Control,Chongqing,China 401121) |
| |
| Abstract: | Objective To determine the content of Menadiol Diacetate Tablets by RP-HPLC.Methods The chromatographic column was Welch Materials C18 column（150 mm×4.6 mm,5 μm） with acetonitrile-water（65 ∶35） as the mobile phase,the detective wavelength was 285 nm and the flow rate was 1.0 mL/min.The amount of injection was 20 μL.Results The calibration curve of menadiol diacetate was linear in the range of 4.0-60.0 μg/mL,the average recovery rate was 99.93%（n=9）.Conclusion The method is simple,accurate,reliable and reproducible,which can be used for the determination both the raw material and preparations and the quality control of Menadiol Diacetate Tablets. |
| |
| Keywords: | menadiol diacetate RP-HPLC content determination |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
