| 马蹄香治疗婴幼儿轮状病毒肠炎作用机制的初步探讨 |
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| 引用本文： | 张佩红,陈啸洪,王燕,李华浚,章杭湖.马蹄香治疗婴幼儿轮状病毒肠炎作用机制的初步探讨[J].中国全科医学,2010,13(6):610-612. |
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| 作者姓名： | 张佩红 陈啸洪 王燕 李华浚 章杭湖 |
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| 作者单位： | 1. 浙江省绍兴市人民医院(绍兴文理学院第一附属医院),312000
2. 绍兴富盛人民医院 |
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| 摘 要： | 目的探讨马蹄香治疗婴幼儿轮状病毒肠炎的作用机制，研究其对轮状病毒肠炎患儿免疫功能的影响。方法采用ELISA法检测粪便轮状病毒特异性抗原，采用透射比浊法测定血清IgG、IgA、IgM和补体C3、C4水平，采用流式细胞术分析淋巴细胞亚群。将86例轮状病毒肠炎患儿随机分为马蹄香治疗组42例，常规治疗组44例，观察两组的临床疗效、轮状病毒的排出时间及治疗前后免疫性指标的变化。结果两纽患儿治疗前血清IgG、IgA、IgM和补体C3、CD3^＋、CD4^＋、CD4^＋／CD8^＋比值水平较对照组明显降低，CD19^＋、CD8^＋水平升高，差异有统计学意义（P〈0．05）。治疗后两组免疫功能均有明显改善，马蹄香治疗组显效35例，有效5例，无效2例，总有效率95．3％；常规治疗组显效30例，有效5例，无效9例，总有效率79．5％；两组总有效率间差异有统计学意义（χ^2=4．7439，P〈0．05）。结论马蹄香治疗婴幼儿轮状病毒肠炎的作用机制可能与抑制轮状病毒的复制，改善机体的免疫功能有关。
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| 关 键 词： | 轮状病毒感染 肠炎 免疫球蛋白类 马蹄香 药理机制 |
Action Mechanism of Valeriana Jatamansii Jones in Treating Rotavirus Enteritis in Infants |
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| ZHANGPei-hong,CHENXiao-hong,WANGYan,etal.People%c'sHospitalofShaoxing,Shaoxing,China.Action Mechanism of Valeriana Jatamansii Jones in Treating Rotavirus Enteritis in Infants[J].Chinese General Practice,2010,13(6):610-612. |
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| Authors: | ZHANGPei-hong CHENXiao-hong WANGYan etalPeople%c'sHospitalofShaoxing Shaoxing China |
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| Institution: | ZHANG+Pei-hong,CHEN+Xiao-hong,WANG+Yan,et+al.People%5c's+Hospital+of+Shaoxing(The+First+Affiliated+Hospital+of+Shaoxing+Academy+of+Arts+,+Sciences),Shaoxing+312000,China |
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| Abstract: | Objective To explore the action mechanism of Valeriana jatamansii jones(VJJ)in treating rotavirus enteritis in infantsMethods Totally 86 infants with rotavirus enteritis were enrolled and randomly divided into VJJ group(n=42)and conventional therapy group(control group;n=44).The clinical effectiveness,excretion of rotavirus,and changes of the immunologic indicators before and after treatment were observed and recorded.Rotavirus-specific antigen was detected using ELISA.The serum levels of immunoglobulins(Ig... |
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| Keywords: | Rotavirus infections Enteritis Immunoglobulins Valeriana jatamansii jones Pharmacologic action |
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