Conditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: A population-based analysis |
| |
| Affiliation: | 1. Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada;2. Unit of Urology/Division of Oncology, Gianfranco Soldera Prostate Cancer Lab, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy;3. Department of Urology, IRCCS Policlinico San Martino, Genova, Italy;4. Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genova, Genova, Italy;5. Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona;6. Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany;7. Department of Urology, University Hospital Frankfurt, Goethe University Frankfurt am Main, Frankfurt am Main, Germany;8. Department of Urology, IEO European Institute of Oncology, IRCCS, Milan, Italy;9. Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany;10. Department of Urology, Koc University Hospital, Istanbul, Turkey;11. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria;12. Department of Urology, Weill Cornell Medical College, New York, NY;13. Department of Urology, University of Texas Southwestern, Dallas, TX;14. Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan |
| |
| Abstract: | PurposeTo assess the effect of event-free survival duration on cancer-specific mortality (CSM) after radical cystectomy (RC) in nonmetastatic muscle-invasive squamous cell carcinoma of the urinary bladder.MethodsRC patients treated for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder were identified within the Surveillance, Epidemiology, and End Results database (2000?2018). Independent predictor status for CSM of T and N stage groupings (i.e., T2N0, T3N0, T4N0, and TanyN1-3) was tested in multivariable Cox-regression models. Conditional 5-year CSM-free estimates were assessed at baseline and at 4 specific event-free survival times (i.e. 6, 12, 18 and 24 months), within each of the 4 examined stage groups.ResultsOf 981 RC patients, 206 (21%), 416 (42%), 152 (16%), and 207 (21%) were T2N0, T3N0, T4N0, and TanyN1-3, respectively. In multivariable Cox-regression models T3N0 (HR 1.94), T4N0 (HR 5.22), and TanyN1-3 (HR 6.62) were independent predictors of CSM, relative to T2N0. In conditional survival analyses based on 24 months event-free status, survival estimates were: 89% for T2N0 vs. 76% at baseline (Δ = 13%), 84% for T3N0 vs. 58% at baseline (Δ = 26%), 69% for T4N0 vs. 25% at baseline (Δ = 44%), 69% for TanyN1-3 vs. 22% at baseline (Δ = 47%).ConclusionsEvent-free status at 24 months of follow-up is associated with substantially higher CSM-free survival than when CSM-free survival is predicted at baseline. The magnitude of this effect is most pronounced in TanyN1-3 and T4N0 patients, intermediate in T3N0 and more modest, nonetheless important, in T2N0. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
