Secondary thalamic atrophy related to brain infarction may contribute to post-stroke cognitive impairment |
| |
| Affiliation: | 1. Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China;2. LC Campbell Cognitive Neurology, Dr. Sandra Black Centre for Brain Resilience & Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Ontario, Canada;3. Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (Sunnybrook site), Toronto, Ontario, Canada;4. Department of Medical Biophysics, University of Toronto, Ontario, Canada;5. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA;6. Hauenstein Neuroscience Center, Saint Mary''s Health Care, Grand Rapids, MI, USA;7. LCC International University;8. Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Ontario, Canada;1. Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, United Kingdom;2. Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom;3. Department of Basic Science, Prince Sultan Bin Abdulaziz College for Emergency Medical Services, King Saud University, Riyadh, Saudi Arabia;4. Liverpool Heart and Chest Hospital, Liverpool, United Kingdom;5. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark;6. TriNetX LLC, London, United Kingdom;7. Department of Medicine, Whiston Hospital, St Helens and Knowsley Teaching Hospitals NHS Trust, United Kingdom;1. Department of Pediatrics, Division of Neonatology, Atatürk City Hospital, Balikesir, Turkey;2. Department of Pediatrics, Division of Pediatric Neurology, Atatürk City Hospital, Balikesir, Turkey;1. Department of Occupational Therapy, St. Vincent''s Hospital, The Catholic University, 93, Jungbu-daero, Paldal-gu, Suwon-si, Gyeonggi-do, Republic of Korea;2. Department of Occupational Therapy, College of Health & Medical Sciences, Cheongju University, 298, Daesung-ro, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, Republic of Korea, 28497;1. Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan;2. Clinical Research Center National Hospital Organization, 2-21 Higashigaoka, Meguro-ku, Tokyo, 152-8621, Japan;3. Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-shi, Tokyo, 192-0392, Japan;1. Lewis Katz School of Medicine at Temple University, 1316 West Ontario Street, 10th floor, Philadelphia, PA 19140, United States;2. Geisinger, United States;3. Department of Geography, Temple University, United States;4. St. Lukes Health System, United States;5. State University of New York-Upstate, United States;6. State University of New York-Stony Brook, United States;7. Cooper Medical Center, United States;8. Christiana Care Health System, United States;9. Einstein Health System, United States;10. Reading Hospital, United States;1. Medical Student, Jeonbuk National University Medical School, Korea;2. Department of Radiology and Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Korea |
| |
| Abstract: | ![]()
Background and purposeThe thalamus is a key brain hub that is globally connected to many cortical regions. Previous work highlights thalamic contributions to multiple cognitive functions, but few studies have measured thalamic volume changes or cognitive correlates. This study investigates associations between thalamic volumes and post-stroke cognitive function.MethodsParticipants with non-thalamic brain infarcts (3-42 months) underwent MRI and cognitive testing. Focal infarcts and thalami were traced manually. In cases with bilateral infarcts, the side of the primary infarct volume defined the hemisphere involved. Brain parcellation and volumetrics were extracted using a standardized and previously validated neuroimaging pipeline. Age and gender-matched healthy controls provided normal comparative thalamic volumes. Thalamic atrophy was considered when the volume exceeded 2 standard deviations greater than the controls.ResultsThalamic volumes ipsilateral to the infarct in stroke patients (n=55) were smaller than left (4.4 ± 1.4 vs. 5.4 ± 0.5 cc, p < 0.001) and right (4.4 ± 1.4 vs. 5.5 ± 0.6 cc, p < 0.001) thalamic volumes in the controls. After controlling for head-size and global brain atrophy, infarct volume independently correlated with ipsilateral thalamic volume (β= -0.069, p=0.024). Left thalamic atrophy correlated significantly with poorer cognitive performance (β = 4.177, p = 0.008), after controlling for demographics and infarct volumes.ConclusionsOur results suggest that the remote effect of infarction on ipsilateral thalamic volume is associated with global post-stroke cognitive impairment |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
