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| 依达拉奉治疗急性脑梗死临床观察 | |
| 引用本文： | 闫建萍,邓宇春,吴和平. 依达拉奉治疗急性脑梗死临床观察[J]. 中国实用神经疾病杂志, 2009, 12(9) |
| 作者姓名： | 闫建萍 邓宇春 吴和平 |
| 作者单位： | 福建龙岩人民医院神经内科,龙岩,364000 |
| 摘 要： | 目的 观察依达拉奉治疗急性脑梗死的有效性和安全性.方法 采用随机、双盲、安慰剂对照试验,选择发病48h内急性脑梗死患者 102 例,随机为为依达拉奉治疗组 52例,对照组 50 例.治疗组给予依达拉奉 30mg静滴,2次/d,共14d,2组同时给予疏血通、阿司匹林.治疗前后定期对患者进行欧洲卒中评分(ESS),日常生活活动能力(ADL)评定和常规检查,以治疗第7、14、21天 ESS增分率与第 90天 ADL增分率作为主要疗效判断标准.结果 21d 治疗组与对照组增分率分别为(58.8±16.2)%、(25.1±11.7)%,2组对比差异有统计学意义(P＜0.01),90d治疗组与对照组增分率分别为(72.5±19.8)%、(46.1±28.6)%,2组相比差异有统计学意义(P＜0.01),治疗组无明显不良反应.结论 依达拉奉治疗脑梗死安全有效. |
| 关 键 词： | 依达拉奉 急性脑梗死 羟自由基清除剂 |
Clinical observation on Edaravone for the patients with acute cerebral infarction |
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| Yan Jianping,Deng Yuchun,Wu Heping. Clinical observation on Edaravone for the patients with acute cerebral infarction[J]. Chinese Journal of Practical Neruous Diseases, 2009, 12(9) | |
| Authors: | Yan Jianping Deng Yuchun Wu Heping |
| Affiliation: | Yan Jianping,Deng Yuchun,Wu Heping.Department of Neurology,Longyan People's Hospital,Longyan 364000,China |
| Abstract: | Objective To verify the efficacy and safety of Edaravone on acute cerebral infarction.Methods We performed a randomized,double-blindstedy,placebo-controlled on ACI patients.One hundred and two patients enrolled within 48h of onset,were allocated to Edaravone group(n=52) or placebo group(n=50) randomly.Edaravone was infused at a dose of 30 mg,twice a day,for 14 days.Meanwhile,Shuxuetong and Aspirin were taken as basic treatment.The treatment of the placebo group was similar to Edaravone group except for Edar... |
| Keywords: | Edaravone Acute cerebral infarction Hydroxy-free radical scavenger |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |