万古霉素相关肾毒性的主动监测研 究简

目的：研究应用计算机辅助系统实现主动监测住院患者万古霉素肾毒性的可行性和关键要素.方法：基于住院患者药品不良事件主动监测与评估警示系统,通过团队论证的方式设定住院患者万古霉素肾毒性主动监测的事件配置器,回顾性调取2012 年10 月1 日－2013 年8 月27 日我院经静脉途径应用万古霉素的住院患者,对系统提示的阳性预警病例进行人工再评价.结果：实际共筛查病例619 例次,系统提示的阳性预警病例为9 例次,经人工再评价的实际阳性病例为4 例次,阳性预警率为0.65%.结论：住院患者药品不良事件主动监测与评估警示系统对万古霉素肾毒性的阳性预警率与文献报道结果相符,应用系统进行主动监测研究中事件配置器的参数设置为关键要素,应基于不同目标药物和药品不良事件特点进行个体化设置.

The active surveillance of vancomycin-related nephrotoxicity

Objective： To study the feasibility and key elements of active surveillance of vancomycin-related nephrotoxicityin hospitalized patients based on computer-aided system. Methods： Based on inpatient＇s active monitor and assessment system ofadverse drug events and the event monitor configurator of vancomycin-related nephrotoxicity set by team work, the retrospectivemethod was used for evaluating the hospitalized patients of PLA General Hospital from October 1, 2012 to August 27, 2013 whointravenously used the vancomycin. The positive warning cases were manually re-evaluated. Results： Among 619 actual screeningcases, there were 9 warning cases auto screened by the system. After manual re-evaluation, the actual positive cases were 4 cases, thepositive warning rate was 0.65%. Conclusion： The positive warning rate of vancomycin-related nephrotoxicity by inpatient＇s activemonitor and assessment system was consistent with that of the literature. Setting parameters of adverse drug events configurator inthis system was the key point and should be based on different target drugs as well as the different characteristics of adverse drug events.