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| 黄芩素衍生物的合成及舒张支气管活性 | |
| 引用本文： | 邓 兰, 余红伟, 龙绍疆, 马燕如, 朱绪民. 黄芩素衍生物的合成及舒张支气管活性[J]. 中国药科大学学报, 2010, 41(5): 414-418. |
| 作者姓名： | 邓 兰 余红伟 龙绍疆 马燕如 朱绪民 |
| 作者单位： | 1.四川滇虹医药开发有限公司 |
| 摘 要： | 以黄芩苷为起始原料，利用其糖基做保护基，选择性地合成了10个具有舒张支气管平滑肌活性的黄芩素衍生物，其结构通过IR，MS和1H NMR数据确证。初步活性结果显示，黄芩素衍生物可以抑制由KCl，乙酰胆碱和组胺所致的豚鼠平滑肌收缩，这提示黄芩素衍生物可能在治疗慢性阻塞性肺病方面有较好的应用前景。 |
| 关 键 词： | 黄芩苷 黄芩素衍生物 慢性阻塞性肺病 舒张支气管 |
A novel synthesis of baicalein derivatives and their bronchodilation activity |
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| A novel synthesis of baicalein derivatives and their bronchodilation activity[J]. Journal of China Pharmaceutical University, 2010, 41(5): 414-418. | |
| Abstract: | Ten baicalein derivatives with bronchodilation activity were selectively synthesized using baicalin as a starting material and applying its glycosyl group as a protecting group.Their structures were confirmed by IR，MS and 1H NMR dataThe preliminary biological assay results showed that the Baicalein derivatives could inhibit contraction of tracheal smooth muscle induced by acetylcholine(Ach)，KCl and histamine(His) in guinea pigThis finding indicates a potential application of Baicalein derivatives in chronic obstructive pulmonary diseases(COPD). |
| Keywords: | baicalin baicalein derivatives chronic obstructive pulmonary diseases bronchodilation |
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