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| 睡眠剥夺对模拟高原环境下高原肺水肿形成的影响 | |
| 引用本文： | 李华君,王东,陈训安,刘福玉,廖建贵,陈泽林,罗勇军,徐刚,陈建,高钰琪. 睡眠剥夺对模拟高原环境下高原肺水肿形成的影响[J]. 西南国防医药, 2010, 20(12): 1277-1279. DOI: 10.3969/j.issn.1004-0188.2010.12.001 |
| 作者姓名： | 李华君 王东 陈训安 刘福玉 廖建贵 陈泽林 罗勇军 徐刚 陈建 高钰琪 |
| 作者单位： | 1. 844800,新疆,泽普,解放军69316部队卫生队;第三军医大学高原医学教育部重点实验室 2. 泽普,解放军69316部队卫生队,新疆,844800 3. 第三军医大学高原医学教育部重点实验室 |
| 基金项目： | 国家自然科学基金，国家科技支撑计划 |
| 摘 要： | 目的探讨睡眠剥夺对模拟高原环境下高原肺水肿（high altitude pulmonary edema,HAPE）形成的影响,为防治HAPE提供理论依据。方法雄性SD大鼠,随机分成4组,即平原对照组、高原对照组、高原剥夺组、平原剥夺组,睡眠剥夺采用小平台水环境法建立,高原环境用5000 m低压氧舱模拟。通过测定大鼠肺湿/干比值、肺含水比值、动脉血气来评定肺水肿的程度,并通过大鼠肺组织石蜡切片观察各组病变。结果高原剥夺组的肺湿/干比值及肺含水量比值显著高于其余3组（P〈0.01）。高原剥夺组可见肺间质增厚、肿大,大量多核细胞,肺泡腔变小,肺泡内无液体渗出,其他组病理切片未见上述变化。结论高原环境下睡眠剥夺可促发急性HAPE的形成可能与交感神经活性增强有关。 |
| 关 键 词： | 睡眠剥夺 高原肺水肿 大鼠 |
Effects of sleep deprivation on development of high altitude pulmonary edema in a simulated high altitude environment in rats |
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| Li Huajun,Wang Dong,Chen Xunan,Liu Fuyu,Liao Jiangui,Chen Zelin,Luo Yongjun,Xu Gang,Chen Jian,Gao Yuqi. Effects of sleep deprivation on development of high altitude pulmonary edema in a simulated high altitude environment in rats[J]. Medical Journal of National Defending forces in Southwest China, 2010, 20(12): 1277-1279. DOI: 10.3969/j.issn.1004-0188.2010.12.001 | |
| Authors: | Li Huajun Wang Dong Chen Xunan Liu Fuyu Liao Jiangui Chen Zelin Luo Yongjun Xu Gang Chen Jian Gao Yuqi |
| Affiliation: | Li Huajun1,2,Wang Dong1,Chen Xun'an1,Liu Fuyu2,Liao Jiangui2,Chen Zelin2,Luo Yongjun2,Xu Gang2,Chen Jian2,Gao Yuqi21.Health Team,Unit 69316 of PLA,Zepu,Xinjian,844700,China,2.Key Laboratory of High Altitude Medicine of Education Ministry,Third Military Medical University,Chongqing,400038 |
| Abstract: | Objective To investigate the impacts of sleep deprivation on the development of high altitude pulmonary edema(HAPE) in a simulated high altitude environment in rats.Methods 44 male SD rats were randomly divided into plain control group,plateau control group,plateau sleep deprivation group,plain sleep deprivation group.The small platform method was used to induce sleep deprivation,and a hypobaric oxygen chamber was used to simulate the high altitude environment of 5000 m above sea level.The degree of pulmona... |
| Keywords: | sleep deprivation high altitude pulmonary edema rat |
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