Hedgehog信号转导通路与肺癌

 【摘要】　Hedgehog（Hh）信号通路在胚胎发育期起关键作用，调节细胞的增殖、分化，协调组织器官如皮肤、脑、神经管、肠、附肢及肺等发育过程中的关键步骤。在成年期，Hh通路调控干细胞的增殖，此时Hh通路受到严格的时空限制。近年来研究表明Hh信号通路异常激活与包括肺癌在内的多种肿瘤的发生、发展密切相关，因此可能会成为肿瘤治疗的一个新靶点。现对Hh信号通路的特性及其在肺癌中的研究现状作一综述。

Hedgehog signaling pathway and lung cancer

Hedgehog (Hh) pathway plays a critical role in embryonic development period,which regulates cell proliferation and differentiation,and coordinates the key step of organs' development process such as skin,brain,neural tube,bowels,appendage and lung.In the adult stage,Hh signaling regulates proliferation of stem cells.At this time,Hh signaling is strictly controlled by time and space.In recent years,studies have shown aberrant activation of the Hh pathway is closely related to various types of malignancies,and would be a new therapeutic target of tumor treatment.This paper will review the characteristic of Hh signaling pathway and its research status in lung cancer.