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Illuminating the Role of Vitamin A in Skin Innate Immunity and the Skin Microbiome: A Narrative Review |
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| Authors: | Fritzlaine C. Roche Tamia A. Harris-Tryon |
| Affiliation: | 1.Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;2.Department of Dermatology, University of Rochester School of Medicine & Dentistry, Rochester, NY 14642, USA;3.Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA |
| Abstract: | Vitamin A is a fat-soluble vitamin that plays an important role in skin immunity. Deficiencies in Vitamin A have been linked to impaired immune response and increased susceptibility to skin infections and inflammatory skin disease. This narrative review summarizes recent primary evidence that elucidates the role of vitamin A and its derivatives on innate immune regulators through mechanisms that promote skin immunity and sustain the skin microbiome. |
| Keywords: | vitamin A retinoic acid skin immunity innate immunity skin microbiome |