Comparison of asymptomatic and symptomatic childhood glomerulonephritis progressing to renal failure: a report of Kyushu Pediatric Nephrology Study Group

We evaluated the clinicopathological features and the outcome of 33 children with primary glomerulonephritis (GN) as the cause of renal failure; 17 had asymptomatic (ASP) haematuria and/or proteinuria and the remaining 16 had symptoms suggestive of GN. The renal histology in the ASP group indicated IgA GN in 6 children, focal segmental glomerular sclerosis (FSGS) in 4, diffuse proliferative GN (DPGN) in 3, membranous GN (MGN) in 1, membranoproliferative GN (MPGN) in 1 and diffuse sclerosing GN in 2. In the symptomatic (SYP) group, FSGS was evident in 9 children, DPGN in 3, MGN in 2, IgA GN in 1 and MPGN in 1. There was no difference in the histological severity between the two groups. Fourteen children in the SYP group had nephrotic syndrome (NS) and/or hypertension at their initial visits. Only 4 children in the ASP group showed NS or hypertension during the period of follow-up. Eleven children in the ASP group and all in the SYP group were treated with immunosuppressive and/or antihypertensive drugs, but these did not improve the prognosis of the ASP children compared with those in the SYP group. There was no significant difference in the mean duration between the onset of the disease and the start of dialysis in these two groups. In conclusion, it is questionable whether the urinary mass screening programme in Japan will alter the outcome of children with GN.Further participating centres: Oita Medical School, Oita, Japan (Makoto Uchiyama); Okinawa Prefectural Chubu Hospital, Naha, Japan (Koichiroh Tamanaha); Kagoshima University, Kagoshima, Japan (Makoto Ninomiya); Nishibeppu National Hospital, Beppu, Japan (Akio Furuse); School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan (Minoru Yamagishi); Saga Medical School, Saga, Japan (Tadashi Satoh); Nagasaki University, Nagasaki, Japan (Kiyoaki Nagano); Miyazaki Medical School, Miyazaki, Japan (Kanehide Hashiguchi); Fukuoka Red Cross Hospital, Fukuoka, Japan (Tetsuro Yanase); Yahata Saiseikai Hospital, Kitakyushu, Japan (Keizo Ohbu); Kokura National Hospital, Kitakyushu, Japan (Kumiko Mukuno)