CD24在食管鳞状细胞癌中的表达及其与预后的关系

 目的　检测CD24在食管鳞状细胞癌组织中表达的情况，探讨其与临床病理参数的关系及对食管鳞状细胞癌预后的临床意义。方法　应用免疫组织化学Envision法检测90例食管鳞状细胞癌组织中CD24的表达情况，分析CD24与食管鳞状细胞癌临床病理特征及预后的关系。结果　CD24在食管鳞状细胞癌组织中的阳性表达率明显高于癌旁组织（χ2＝0.832，P＜005）。CD24在食管鳞状细胞癌的阳性表达与患者的年龄、性别、有无脉管浸润、组织学分级无关（χ2分别为0.741、0.361、0.930、8.858，均P＞0.05），而与淋巴结转移（χ2＝12.349，P＝0.000）、TNM分期（χ2＝10.804，P＝0.005）和浸润深度（χ2＝13.94，P＝0.007）呈正相关；不同CD24表达组之间（+、++、++）的生存率差异有统计学意义，OR（95 % CI）分别为2.105（61.022～69.273），2.313（55.108～64.176），1.286（32.388～37.429），CD24表达强阳性食管鳞状细胞癌患者生存率明显低于CD24表达强度较低组。CD24、浸润深度、淋巴结转移是影响食管鳞状细胞癌预后的独立预后因素。结论　CD24可能提示食管鳞状细胞癌发展的恶性进程，其高表达提示食管鳞状细胞癌患者预后不良，有望成为一个新的相对独立的食管鳞状细胞癌预后预测指标。

Expression of CD24 in esophageal squamous cell carcinoma and its relationship with prognosis

Objective　To study the significance of CD24 protein expressions in esophageal squamous cell carcinoma and their relationship with clinical pathological parameters and clinical prognosis. Methods　The expressions of CD24 protein were studied in 90 esophageal squamous cell carcinoma samp1es by Envision immunohistochemical(IHC) ana1ysis and to study relationship of CD24 with clinical pathological parameters and prognosis. Results　The expression of CD24 in esophageal squamous cell carcinoma were significantly higher than that in adjacent normal tissue. The expression of CD24 was not related with the age of patien, sexuality and the histologic grade,but with clinical stage of the cance (χ2 = 10.804, P = 0.005), lymph node metastasis (χ2 = 12.349, P = 0.000) and depth of tumor invasion (χ2 = 13.94, P = 0.007). Significant difference in survival between the different CD24 expression group (χ2 = 71.466, P = 0.000), the survival of patients with strong expression of CD24 was inferior to that of weak expression of CD24, depth of tumor invasion and lymph node metastasis were independent prognostic factors of esophageal squamous cell carcinoma. Conclusion　CD24 may be related to the malignant process of esophageal squamous cell carcinoma. Overexpression of CD24 indicates poor prognosis in esophageal squamous cell carcinoma patients. CD24 may become a new independent prognostic factor for esophageal squamous cell carcinoma.