大分割适形放射治疗在非小细胞肺癌中的应用

大分割适形放疗技术较常规分割技术能给予肿瘤更高的生物有效剂量，近年来研究显示，对早期不能手术非小细胞肺癌（NSCLC）患者，大分割适形放疗高效低毒，是可选择的治疗方案。许多临床Ⅰ、Ⅱ期研究显示，局部晚期NSCLC患者对大分割适形放疗耐受性良好。放射物理学模型和相关临床研究显示，与常规分割放疗模式相比大分割适形放疗不会增加放射性肺炎发生率。

Application of hypofractionated conformal radiotherapy in non-small cell lung cancer

Hypofractionated conformal radiotherapy is capable to deliver much higher doses to the cancer than is possible with standard techniques. Recently there is data suggesting that the early stage nonsmall cell lung cancer ( NSCLC) which is not suitable to surgery is likely to benefit from this regimen, with low lung toxicity. Manyphase Ⅰ-Ⅱ studies showed that the patients with locally advanced NSCLC are well-tolerated to hypofractionated conformal radiotherapy. The model of radio-physic and relative clinical studies suggest that hy-pofractionation would not increase the risk of radiation pneumonitis compared to standard therapy.