| 非小细胞肺癌中MMP-9、TIMP-1的表达与临床病理关系 |
| |
| 引用本文： | 贺伯伟,李莉,吴德文,王丽娜.非小细胞肺癌中MMP-9、TIMP-1的表达与临床病理关系[J].陕西医学杂志,2007,36(9):1232-1235. |
| |
| 作者姓名： | 贺伯伟 李莉 吴德文 王丽娜 |
| |
| 作者单位： | 西安医学院附属医院,西安,710077 |
| |
| 摘 要： | 目的:探讨基质金属蛋白酶-9(MMP-9)和组织金属蛋白酶抑制剂-1(TIMP-1)的表达与非小细胞肺癌(NSCLC)临床病理学特征之间的关系。方法:采用免疫组织化学方法,检测41例NSCLC标本及19例癌旁组织中MMP-9、TIMP-1的表达水平,并探讨其与NSCLC的临床病理学特征之间的关系。结果:41例NSCLC中,MMP-9和TIMP-1的阳性表达率分别为65.9%和58.5%,MMP-9和TIMP-1的高表达与淋巴结转移、病理类型显著相关(P<0.05)。结论:MMP-9、TIMP-1与NSCLC侵袭转移密切相关。
|
| 关 键 词： | 癌 非小细胞肺/诊断 癌 非小细胞肺/病理学 基质金属蛋白酶/代谢 金属蛋白酶组织抑制剂/代谢 免疫组织化学 |
| 修稿时间： | 2007-04-20 |
Expression of MMP-9 and TIMP-1 in relation to clinicopathological factors of non-small-cell lung cancer |
| |
| He Bowei ,Li Li, Wu Dewen et al.Expression of MMP-9 and TIMP-1 in relation to clinicopathological factors of non-small-cell lung cancer[J].Shaanxi Medical Journal,2007,36(9):1232-1235. |
| |
| Authors: | He Bowei Li Li Wu Dewen |
| |
| Institution: | Xi'an 710077 |
| |
| Abstract: | Objective: To investigate the expression of MMP-9 and TIMP-1 in non-small-cell lung cancer(NSCLC) and the relationship with their clinicopathological factors.Methods: Immunohistochemistry staining was used to detect the expression of MMP-9 and TIMP-1 in 41 cases of NSCLC and 19 cases of paracancerous tissues.Results: In 41 cases with NSCLC,the expression rate of MMP-9 and TIMP-1 were 65.9% and 58.5% respectively.It was significant higher in NSCLC than that in paracancerous tissues(P<0.05).Lymph node involvement and histological type had a significant positive correlation with overexpression of MMP-9 and TIMP-1(P<0.05).Conclusion: MMP-9 and TIMP-1 correlate positively and play important roles in the development and progression of NSCLC. |
| |
| Keywords: | Carcinoma non-small-cell lung/diagnosis Carcinoma non-small-cell lung/pathology Matrix metalloproteinases/metabolism Tissue-inhibitor of metalloproteinase-1/metabolism Immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
