Mucosal iron binding proteins and the inhibition of iron absorption by endotoxin

Summary The uptake of iron from a tied off jejunal segment into the body after the injection of a ⁵⁹Fe labeled test dose was decreased after the administration of endotoxin by about 80% in both normal and iron deficient animals. — In the iron deficient group the distribution of ⁵⁹Fe in the cytosol fraction of jejunal mucosa between transferrin and ferritin was determined chromatographically; the amount of ⁵⁹Fe in the ferritin fraction increased remarkably after the endotoxin treatment and the ratio of both was changed in favor of ferritin. — It is hypothesized that the association of the diversion of iron to the mucosal ferritin with the decrease of the transport of iron into the blood caused by endotoxin might be the consequence of abnormal oxidations in the mucosa measured by others in liver tissue.