| 金丝桃抗脂质过氧化作用研究 |
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| 引用本文： | 项光亚,杨瑜,阮金兰,周宜开. 金丝桃抗脂质过氧化作用研究[J]. 华中科技大学学报(医学版), 2001, 30(3): 211-213 |
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| 作者姓名： | 项光亚 杨瑜 阮金兰 周宜开 |
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| 作者单位： | 1. 华中科技大学同济医学院环境医学研究所,
2. 华中科技大学同济医学院药学院, |
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| 基金项目： | 国家自然科学基金资助项目（No.39990570） |
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| 摘 要： | 为研究金丝桃的抗脂质过氧化作用，用分光光度法测定了金丝桃提取物对大鼠离体组织匀浆的脂质过氧化及由Fe2+-H2O2体系、Fe2+-VitC体系和Fe2+-Cys体系诱导的脂质过氧化的抑制作用。发现金丝桃提取物对大鼠肝、心、肾组织匀浆脂质过氧化和线粒体诱导的脂质过氧化具有抑制作用并表现出剂量依赖关系，而且提取物F003的抑制作用要强于F004、F005的抑制作用。认为金丝桃具有较好的抗脂质过氧化作用，具有进一步研究与开发价值。
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| 关 键 词： | 金丝桃 丙二醛 脂质过氧化 抗脂质过氧化 自由基 |
| 修稿时间： | 2000-07-03 |
Studies on the Effect of Hypericum Chinense on Antilipid-Peroxidation |
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| Xiang Guangya ,Yang Yu ,Ruan Jinlan et al Institute of Enviromental Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Pharmaceutical College of Tongji Medical College,Huazhong Unive. Studies on the Effect of Hypericum Chinense on Antilipid-Peroxidation[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2001, 30(3): 211-213 |
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| Authors: | Xiang Guangya Yang Yu Ruan Jinlan et al Institute of Enviromental Medicine Tongji Medical College Huazhong University of Science Technology Wuhan Pharmaceutical College of Tongji Medical College Huazhong Unive |
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| Affiliation: | Xiang Guangya 1,Yang Yu 2,Ruan Jinlan 2 et al 1 Institute of Enviromental Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 2 Pharmaceutical College of Tongji Medical College,Huazhong Unive |
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| Abstract: | The antilipid peroxidation of the extracts of Hypericum Chinense was studied. The antilipid peroxidation of Hypericum Chinense on liver, kidney, heart and mitochondria was measured by the determination of malondialdehyde (MDA) using TBA spectrometric method. The results showed that the extracts of Hypericum Chinense could inhibit the lipid peroxidation of liver, kidney, heart tissue homogenate and the lipid peroxidation of mitochondria induced by Fe 2 H 2 O 2 , Fe 2 VitC and Fe 2 Cys. The inhibition exhibited concentration dependent manner. The inhibitory effect of the extracts of F003 was stronger than that of the extracts of F004 and F005. It was suggested that Hypericum Chinense had a good antilipid peroxidation effect, therefore it may be necessary to study it further. |
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| Keywords: | Hypericum Chinense malondialdehyde lipid peroxidation antioxidation free radicals |
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