Molecular Analysis of Caprine Enterovirus Circulating in China during 2016–2021: Evolutionary Significance |
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| Authors: | Xiaoran Chang Qian Lin Qun Zhang Junying Hu Gulbahar Tursun Yingrui Deng Chunguang Guo Xinping Wang |
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| Affiliation: | State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130012, China; (X.C.); (Q.L.); (Q.Z.); (J.H.); (G.T.); (Y.D.); (C.G.) |
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| Abstract: | ![]()
Here, we report the characterization of 13 novel caprine/ovine enterovirus strains isolated from different regions in China during 2016–2021. Immunoperoxidase monolayer assay showed that these viral strains shared strong cross-reaction with the previously reported caprine enterovirus CEV-JL14. Alignment analysis of the complete nucleotide sequences revealed 79.2%–87.8% and 75.0%–76.7% sequence identity of these novel caprine enterovirus strains to CEV-JL14 and TB4-OEV, respectively. Phylogenetic analyses clustered these novel strains to EV-G based on the amino acid sequences of P1 and 2C+3CD. Moreover, phylogenetic analysis of these caprine enterovirus strains identified three new EV-G types using VP1 sequences. These results demonstrate the genetic variations and the evolution of caprine enterovirus. |
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| Keywords: | caprine/ovine enterovirus CEV-JL14 phylogenetic analysis genotype evolution alignment analysis |
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