Microscopic magnetic resonance imaging of the thoracic venous system in rats with congenital diaphragmatic hernia |
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| Authors: | A. L. Luis M. Bret E. Cuesta R. M. Aras Liu Xiaomei J. L. Encinas L. Martinez J. A. Tovar |
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| Affiliation: | (1) Department of Pediatric Surgery, Hospital Universitario “La Paz”, Paseo de la Castellana, 261, 28046 Madrid, Spain;(2) Department of Radiology, Hospital Universitario “La Paz”, Madrid, Spain;(3) Central Laboratory, Shengjing Hospital of China Medical University, Shenyang, 110004, China;(4) Research Laboratory IdiPaz, Hospital Universitario La Paz, Madrid, Spain; |
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| Abstract: | ![]()
Background/aim Infants and rats with congenital diaphragmatic hernia (CDH) have malformations of the heart and the great arteries caused by neural crest (NC) dysregulation during embryogenesis. Abnormally narrow jugular veins have been found in babies during cannulation for ECMO. However, the venous system has not been examined in depth so far. We hypothesized that abnormal patterning and/or size of the thoracic veins could occur in rats with CDH. This hypothesis was tested by microscopic magnetic resonance imaging (MMRI), a high-resolution tool able to detect subtle changes of vessels in small animals. |
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