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| 氧蒽酮-2-羧酸类衍生物及二苯酮类衍生物的合成 | |
| 引用本文： | 葛大伦,梁晓天,卢玉华,祁建新. 氧蒽酮-2-羧酸类衍生物及二苯酮类衍生物的合成[J]. 药学学报, 1987, 22(11): 822-826 |
| 作者姓名： | 葛大伦 梁晓天 卢玉华 祁建新 |
| 作者单位： | 中国医学科学院药物研究所,北京 |
| 摘 要： | 本文合成了一系列取代的氧蒽酮-2-羧酸化合物和二苯酮类化合物。用大鼠的被动皮肤过敏(简称PCA)反应试验抗过敏活性,显示了化合物(Ⅱ)注射有活性,化合物(Ⅳ,Ⅴ)口服有活性。 |
| 关 键 词： | 氧蒽酮-2-羧酸 二苯酮 被动皮肤过敏(PCA) 抗过敏 |
| 收稿时间： | 1986-11-28 |
SYNTHESIS OF DERIVATIVES OF XANTHONE-2-CABOXYLIC ACIDS AND DIPHENYL KETONES |
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| GE Da-Lun,LIANG Xiao-Tian,LU Yu-Hua,and QI Jian-Xin. SYNTHESIS OF DERIVATIVES OF XANTHONE-2-CABOXYLIC ACIDS AND DIPHENYL KETONES[J]. Acta pharmaceutica Sinica, 1987, 22(11): 822-826 | |
| Authors: | GE Da-Lun LIANG Xiao-Tian LU Yu-Hua and QI Jian-Xin |
| Abstract: | A series of substituted xanthone-2-carboxylic acids and diphenyl ketones were synthesized and bioassayed for antiallergic activity, using the passive cutaneous anaphylaxis (PCA) reation in rats. The results showed that i. v. compound Ⅱ and p. o. compounds Ⅳ and Ⅴ have inhibitory activity on PCA. |
| Keywords: | Diphenyl ketone Passive cutaneous anaphylaxis (PCA) Antiallergic Xanthone-2-carboxylic acid |
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