| 水分散体包衣制备奥昔布宁渗透泵片 |
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| 引用本文： | 丁雪鹰,高申,缪春辉,管斐,陈宙艳,张仰眉.水分散体包衣制备奥昔布宁渗透泵片[J].中国药学杂志,2005,40(3):200-202. |
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| 作者姓名： | 丁雪鹰 高申 缪春辉 管斐 陈宙艳 张仰眉 |
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| 作者单位： | 1. 第二军医大学药学院药剂学教研室,上海,200433
2. 解放军第九二医院药械科,福建,南平,353000 |
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| 摘 要： | 目的 以丙烯酸树脂水分散体EudragitRS30D为包衣材料制备奥昔布宁渗透泵片。方法 以丙烯酸树脂水分散体EudragitRS30D为包衣材料制备奥昔布宁渗透泵片,采用相似因子法考察包衣方面因素对体外释药的影响,并与同类进口片进行比较。结果 衣膜中增塑剂种类、衣膜材料和释放介质对释药影响显著,自制片体外恒速释药24h,与同类进口片释放行为相似。结论 采用水分散体包衣制备渗透泵片,同样达到了预期的控释目的,为研究开发新型的控释制剂奠定了基础。
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| 关 键 词： | 水分散体 奥昔布宁 渗透泵片 相似因子 |
| 文章编号： | 1001-2494(2005)03-0200-03 |
| 收稿时间： | 2004-02-04; |
Studies on oral osmotic pump tablet of oxybutynin coated with Eudragit RS 30D |
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| DING Xue-ying,GAO Shen,MIAO Chun-hui,GUAN Fei,CHEN Zhou-yan,ZHANG Yang-mei.Studies on oral osmotic pump tablet of oxybutynin coated with Eudragit RS 30D[J].Chinese Pharmaceutical Journal,2005,40(3):200-202. |
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| Authors: | DING Xue-ying GAO Shen MIAO Chun-hui GUAN Fei CHEN Zhou-yan ZHANG Yang-mei |
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| Institution: | DING Xue-ying1,GAO Shen1,MIAO Chun-hui2,GUAN Fei1,CHEN Zhou-yan1,ZHANG Yang-mei1 |
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| Abstract: | OBJECTIVE To prepare the oxybutynin osmotic pump tablet coated with Eudragit RS 30D.METHODS Oxybutynin osmotic pump tablet was prepared with Eudragit RS 30D as coating material.The influences of the film on release in vitro were investigated by use of similarity factor method.RESULTS The types of plasticizer,coating material and release medium had significant effect on the release rate of oxybutynin from osmotic pump tablet.The drug was released from OPT at the controlled rate over 24 h.The release curve of self-prepared OPT was substantially similar to that of the imported Ditropan XL.CONCLUSION It provided the new technologies for osmotic pump tablet. |
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| Keywords: | Eudragit RS 30D oxybutynin osmotic pump tablet similarity factor |
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