微生态制剂联合美沙拉嗪在溃疡性结肠炎治疗中的作用

目的 研究微生态制剂联合美沙拉嗪在溃疡性结肠炎（UC）治疗中的作用。方法 将126例UC患者随机分为两组，对照组口服美沙拉嗪缓释颗粒4 g/d；联合组在对照组的基础上，口服枯草杆菌二联活菌肠溶胶囊500 mg，3次/d。疗程1个月。监测患者治疗前后血红蛋白(HB)、白蛋白(ALB)、超敏C反应蛋白(hs CRP)和红细胞沉降率(ESR)、白细胞介素（IL） 6、IL 10、血清钙结合蛋白S100A12水平。结果 联合组总有效率高于对照组（P＜0.01），与对照组比较，联合组治疗后ALB及IL 10增高（P＜0.05），而hs CRP、ESR、IL 6、血清S100A12水平均降低。结论 微生态制剂能提高美沙拉嗪治疗UC的有效率，安全可靠。

Role of microbiological agents combined with mesalazine sustained release granules in treatment of ulcerative colitis

Objective To study the role of microbiological agents combined with mesalazine in the treatment of ulcerative colitis (UC). Methods A total of 126 UC patients were enrolled amd randomly divided into two groups, and the control group was given 4 g/d of mesalazin sustained release granules. On the basis of the control group. the combined group also took 500 mg of live combined bacillus subtilis and enterococcus faecium enteric coated capsules 3 times per day for one month. The levels of hemoglobin (HB), albumin (ALB),hypersensitive C reactive protein (hs CRP), erythrocyte sedimentation rate (ESR). interleukin (IL) 6, IL 10 and serum calcium binding protein were monitored before and after the treatment. Results The total effective rate in combined group was significantly higher than that of control group (P<0.01). Compared with control group, ALB and IL 10 witnessesd increases in combined group (P<0.05), while hs CRP, ESR, IL 6 and serum S100A12 decreased. Conclusion Microbiological agents can improve the efficiency, safety and reliability of mesalazin in the treatment of UC.