豆制品摄入量与胃癌发病风险关系的Meta分析

目的 通过Meta分析探讨豆制品摄入量与胃癌发病风险的关系。 方法 两名研究者分别检索PubMed、Web of Science和Embase数据库、中国知网、万方数据库发表的相关文献,用合并OR值和95%CI评价豆制品摄入量与胃癌发病的关系。根据设计类型、研究对象性别和地理区域进行亚组分析。 结果 共纳入53项研究,包括18项队列研究(890 145位参与者中共有5 153例病例)和35项病例对照研究(共有10 692位病例和25 324例对照)。最终共计50项研究(剔除3项质量评分较低的研究)纳入到本次Meta分析中。结果显示:大豆、豆腐和豆浆的高摄入量与胃癌发病风险的降低有关(大豆, OR=0.75,95% CI: 0.66~0.85;豆腐,OR=0.77,95% CI:0.68~0.88;豆浆,OR=0.78,95% CI:0.65~0.94)。亚组分析结果表明,在亚洲人群中较高的大豆和豆腐摄入量与胃癌发病风险呈负相关(大豆,OR=0.80,95% CI: 0.74~0.86;豆腐,OR=0.77,95% CI:0.68~0.88)。 结论 豆制品摄入量增加能降低胃癌的发病风险。

Consumption of soybean products and gastric cancer risk: a systematic review and meta-analysis

Objective To investigate the association between consumption of soybean products and risk of gastric cancer(GC). Methods Relevant literature was searched in PubMed, Web of Science, Embase, CNKI and Wanfang Database from the inception to March 2017. The association between soybean product consumption and GC risk was analyzed with pooled odds ratio(OR)and 95% confidence interval(CI). Subgroup analyses were further performed according to different types of design, genders and geographic regions. Results A total of 53 studies were obtained, including 18 cohort studies with 5 153 cases and 890 145 participants, and 35 case-control studies with 10 692 cases and 25 324 controls. Finally 3 studies with low quality were excluded and 50 studies were included in the systematic review and meta-analysis. The results indicated that higher soybean, tofu and soybean milk consumptions were associated with a decreased risk of GC(soybean, OR=0.75, 95%CI: 0.66-0.85; tofu, OR=0.77, 95%CI: 0.68-0.88; soybean milk, OR=0.78, 95%CI: 0.65-0.94). Subgroup analyses suggested that higher soybean and tofu consumptions were negatively associated with GC risk(soybean, OR=0.80, 95%CI: 0.74-0.86; tofu, OR=0.77, 95%CI: 0.68-0.88)among Asians. Conclusion High intake of soybean, tofu and soybean milk can reduce the risk of GC.