不同剂量牛肺表面活性物质治疗晚期早产儿呼吸窘迫综合征的临床研究

目的 研究不同剂量牛肺表面活性物质治疗晚期早产儿呼吸窘迫综合征的临床疗效。方法 选取2016年1月~2018年1月在我院诊治的90例晚期早产儿呼吸窘迫综合征患儿，依据使用药物剂量分为观察组和对照组，每组45例。对照组给予标准剂量70 mg/kg，观察组给予100 mg/kg，对比两组患儿用药后5 h、10 h、20 h、40 h MAP、FiO2，PCO2、OI、PO2、通气时间以及并发症发生率。结果 观察组用药后5 h、10 h、20 h、40 h MAP、FiO2低于对照组，差异有统计学意义（P＜0.05）；观察组PCO2、OI均低于对照组，PO2高于对照组，通气时间短于对照组，差异有统计学意义（P＜0. 05）；观察组并发症发生率为8.89%，低于对照组的20.00%，差异具有统计学意义（P＜0.05）。结论 临床采用牛肺表面活性物质治疗晚期早产儿呼吸窘迫综合征，剂量应满足100 mg/kg，可有效缩短通气时间，改善肺顺应性，降低并发症的发生，临床安全性良好。

Clinical Study on Treatment of Respiratory Distress Syndrome in Late Preterm Infants with Different Doses of Bovine Lung Surfactant

Abstract:Objective To study the clinical efficacy of different doses of bovine lung surfactant in the treatment of respiratory distress syndrome in late preterm infants.Methods A total of 90 children with respiratory distress syndrome in the late preterm infants who were diagnosed and treated in our hospital from January 2016 to January 2018 were divided into observation group and control group according to the dose of medication.There were 45 cases in each group.The control group was given a standard dose of 70mg/kg,and the observation group was given 100mg/kg.The MAP,FiO2,PCO2,OI,PO2,ventilation time,and incidence of complications were compared at 5 h,10 h,20 h,and 40 h after treatment in both groups.Results The MAP and FiO2 levels in the observation group were lower than those in the control group at 5 h,10 h,20 h,and 40 h after administration,the difference was statistically significant(P<0.05); PCO2 and OI were lower in the observation group than in the control group,PO2 was higher than in the control group,ventilation time was shorter than the control group,and the difference was statistically significant(P<0.05);The complication rate in the observation group was 8.89%,which was lower than that in the control group 20.00%,the difference was statistically significant(P<0.05).Conclusion The use of bovine lung surfactant in the treatment of respiratory distress syndrome in late preterm infants should be performed in a dose of 100mg/kg,which can effectively shorten the ventilation time, improve lung compliance,reduce the occurrence of complications,and have good clinical safety.