Histocompatibility antigens HLA-A, -B, -DR in Greek patients with Kaposi''s sarcoma |
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| Authors: | Chrysa Papasteriades A. Kaloterakis Anna Filiotou Joanna Economidou G. Nicolis D. Trichopoulos J. Stratigos |
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| Affiliation: | Department of Immunology Evangelismos Hospital, Athens;Second Department of Medicine, University of Athens Medical School, Athens, Greece;University Clinic of Dermatology - Venereology, University of Athens Medical School, Athens, Greece;Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece |
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| Abstract: | ![]()
Thirty-two Greek patients with histologically documented Kaposi's sarcoma, aged 46 to 82 years, were typed for HLA-A, B and DR antigens. None of them was homosexual and they had not been subjected to any immunosuppressive therapy. The study revealed a significant increase of HLA-DR5 (53.1% vs. 21.4%, R.R. 4.1) and a decreased frequency of HLA-DR1 (3.3% vs. 16.6%, R.R. 0.16). An increased frequency of HLA-B18 was also noted (43.7% vs. 20.7% R.R. 2.96). These results indicate that the same positive association with HLA-DR5 antigen is observed in Greek patients as in other patients of Mediterranean origin and support the view that HLA linked factor(s) may have a role in the development of the disease. |
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