| 小胶质细胞激活在多巴胺神经元变性损伤中的作用 |
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| 引用本文： | 张丽慧,赵建波.小胶质细胞激活在多巴胺神经元变性损伤中的作用[J].杭州医学高等专科学校学报,2011(1):58-63. |
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| 作者姓名： | 张丽慧 赵建波 |
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| 作者单位： | 杭州师范大学医学神经生物学市级重点实验室,基础医学部,浙江杭州310036 |
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| 基金项目： | 杭州市重点实验室项目;杭州师范大学国家项目培育基金（2010PYjj41） |
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| 摘 要： | 帕金森病（Parkinson’s disease，PD）的主要病理特征是黑质纹状体通路的多巴胺（dopamine，DA）神经元退行性变性和缺失。研究表明，小胶质细胞（microglia）激活在DA神经元变性损伤中起关键作用。在受到各种病理因素刺激时，小胶质细胞大量激活，产生前炎性细胞因子和神经毒性因子，启动或加重神经元损伤，导致DA神经元进行性变性死亡。文章综述了近年来关于小胶质细胞激活对DA神经元损伤作用的研究进展，以期对PD发病机制及治疗药物研究提供参考。
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| 关 键 词： | 小胶质细胞 激活 多巴胺神经元 帕金森病 炎症 |
Role of Microglial Activation in Dopaminergic Cell Degeneration |
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| ZHANG Li-hui,ZHAO Jian-bo.Role of Microglial Activation in Dopaminergic Cell Degeneration[J].Journal of Hangzhou Medical College,2011(1):58-63. |
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| Authors: | ZHANG Li-hui ZHAO Jian-bo |
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| Institution: | ( Hangzhou Key Laboratory of Medical Neurobiology and School of Basic Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China) |
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| Abstract: | Parkinson＇ s disease （PD） is a ncurodegenerative disorder characterized by a progressive degeneration and loss of dopaminergie neurons in the nigrostriatal dopaminergic pathway. Mieroglia are strongly implicated in the pathology and progressively neurodegenerative nature of PD. Specifically, mieroglia can become deleteriously activated in response to disease- specific stimuli to produce a variety of proinflammatory and neurotoxic factors that are believed to induce and exacerbate neurodegeneration. This following review summarizes recent advances on the study of the role of mieroglial activation in dopaminergic neurodegeneration of PD and discusses novel approaches to potential therapeutic strategies. |
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| Keywords: | microglia activation dopaminergic neurons degeneration parkinson＇s disease inflammation |
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