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| 槲皮素纳米结晶混悬剂灌胃给药大鼠体内药物动力学研究 | |
| 引用本文： | 卢贞,翟光喜. 槲皮素纳米结晶混悬剂灌胃给药大鼠体内药物动力学研究[J]. 泰山医学院学报, 2012, 33(3): 202-203 |
| 作者姓名： | 卢贞 翟光喜 |
| 作者单位： | 1. 泰安荣军医院,山东泰安,271000 2. 山东大学药学院,山东济南,250012 |
| 摘 要： | 目的 观察槲皮素纳米结晶混悬剂(QT-NS)与槲皮素(QT)原料药,在大鼠体内药物动力学过程.方法 灌胃给药Wistar大鼠QT-NS与QT原料药.结果 口服QT-NS与QT原料药相比,QT - NS能明显改变药物在大鼠体内药物动力学过程.结论 QT-NS能促进药物的吸收,有效地提高了口服生物利用度. |
| 关 键 词： | 槲皮素 纳米结晶混悬剂 Wisttar大鼠 药物动力学 |
Quercetin nano crystalline suspension intragastric administration of rats in vivo pharmacokinetic study |
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| LU-zhen , ZHAI Guang-xi. Quercetin nano crystalline suspension intragastric administration of rats in vivo pharmacokinetic study[J]. Journal of Taishan Medical College, 2012, 33(3): 202-203 | |
| Authors: | LU-zhen ZHAI Guang-xi |
| Affiliation: | 1.Taian Disabled Soldiers Hospital,Taian 271000,China; 2.College of Pharmacy,Shandong University,Jinan 250012,China) |
| Abstract: | Objective: To observe the effect of quercetin nano crystalline suspension with QT raw materials on the rat in vivo pharmacokinetics.Methods:The intragastric administration of Wistar rat QT nano crystalline suspension with quercetin api was applied.Results:Oral QT nano crystalline suspension with QT raw materials,nano crystalline suspension significantly altered the drug in the rat in vivo pharmacokinetics.Conclusion: Quercetin nano crystalline suspension can promote drug absorption,effectively improving the oral bioavailability. |
| Keywords: | Quercetin nano crystalline suspension Wistar rat pharmacokinetics |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |