| 新型生物陶瓷对体外培养成骨细胞影响的试验研究 |
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| 引用本文： | 谭小兵,吴恩格,赵德萍,贾伟.新型生物陶瓷对体外培养成骨细胞影响的试验研究[J].昆明医学院学报,2004,25(1):41-44. |
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| 作者姓名： | 谭小兵 吴恩格 赵德萍 贾伟 |
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| 作者单位： | 1. 昆明医学院口腔学院,昆明,650031
2. 昆明医学院第一附属医院临床医学试验中心,昆明,650032 |
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| 摘 要： | 目的 :研究新型复合生物陶瓷 (ZrO2 -CBC)对体外培养的胎鼠成骨细胞增殖分化的影响 ,探讨ZrO2 -CBC的细胞相容性 .方法 :将ZrO2 -CBC与胎鼠成骨细胞体外共同培养 15d ,通过细胞计数、ALP活性检测和流式细胞仪法评价ZrO2 -CBC对成骨细胞增殖分化的影响 .结果 :与空白对照组相比 ,实验早期ZrO2 -CBC对成骨细胞增殖分化无抑制作用 (P >0 0 5 ) ,后期轻度抑制成骨细胞的增殖 ,并抑制成骨细胞ALP的分泌 (P <0 0 5 ) .结论 :ZrO2 -CBC是一种有前途的牙科种植体材料
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| 关 键 词： | 生物陶瓷 体外培养 成骨细胞 试验研究 碱性磷酸酶 氧化锆 |
| 文章编号： | 1003-4706(2004)01-0041-04 |
| 修稿时间： | 2003年10月30 |
Experimental Study of the Effect of Novel Bioceramics on Osteoblasts in Vitro |
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| TAN Xiao-bing ,WU En-ge ,ZHAO De-ping ,JIA Wei.Experimental Study of the Effect of Novel Bioceramics on Osteoblasts in Vitro[J].Journal of Kunming Medical College,2004,25(1):41-44. |
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| Authors: | TAN Xiao-bing WU En-ge ZHAO De-ping JIA Wei |
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| Institution: | TAN Xiao-bing 1),WU En-ge 1),ZHAO De-ping 2),JIA Wei 2) |
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| Abstract: | Objective: To evaluate the cell compatibility of ZrO 2-CBC by studying the effect of ZrO 2-CBC on the proliferation and differentiation of fetal rats' osteoblasts in vitro. Methods: Cell counting, measurement of ALP activity and flow cytometry were used to estimate the effect of ZrO 2-CBC on proliferation and differentiation of osteoblasts by coculturing cells with ZrO 2-CBC for 15?days. Results: It was found that ZrO 2-CBC had no inhibitory effect on osteoblasts at the early phase (P>0.05), but it would restrain the proliferation and ALP secretions of osteoblasts at the later phase (P<0.05) compared to blank control group. Conclusion: ZrO 2-CBC is a kind of promising dental implant material. |
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| Keywords: | ZrO 2 Compound bioceramics Osteoblasts Alkaline phosphatase |
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