Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome |
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| Authors: | Muzaffer Temur Özgür Yilmaz Saliha Aksun Pelin Özün Özbay Mehmet Calan Tuncay Küme |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Manisa Merkezefendi State Hospital, Manisa, Turkey, drmuzaffer@yahoo.com;3. Department of Obstetrics and Gynecology, Manisa Merkezefendi State Hospital and Manisa Akhisar State Hospital, Manisa, Turkey,;4. Department of Medical Biochemistry, ?zmir Katipcelebi University Medical School, ?zmir, Turkey,;5. Department of Obstetrics and Gynecology, Ayd?n Obstetrics and Pediatrics Hospital, Ayd?n, Turkey,;6. Department of Endocrinology, ?zmir Bozyaka Education and Research Hospital, ?zmir, Turkey,;7. Department of Medical Biochemistry, Dokuz Eylul University Medical School, Izmir, Turkey, |
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| Abstract: | ![]()
This study was aimed to compare serum urocortin-3 (UCN3) levels in women with polycystic ovary syndrome (PCOS) and healthy women, and establish what role UCN3 levels play in PCOS. Fifty-two patients with PCOS and 55 healthy women were included in the study, matched for age and body mass index. Fasting blood glucose (FBG), insulin, hs-CRP, UCN3 and free-testosterone levels of the all participants were measured. HOMA-IR was used to calculate the insulin resistance. Circulating UCN3 levels were significantly increased in women with PCOS than in control subjects (54.49?±?5.77 versus 51.28?±?5.86?pmol/l, p?=?0.005). Serum insulin, hs-CRP and HOMA-IR levels were higher in women with PCOS than in control group. UCN3 levels positively correlated with hs-CRP in PCOS group (r?=?0.391, p?=?0.004). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curves were 0.732 (95% CI 0.634–0.830, p?
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| Keywords: | hs-CRP insulin PCOS urocortin-3 |
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