| 苯并呋喃衍生物的合成 |
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| 引用本文： | 崔颖,佟巍,林明,王鹏. 苯并呋喃衍生物的合成[J]. 武警医学院学报, 2014, 0(1): 13-17 |
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| 作者姓名： | 崔颖 佟巍 林明 王鹏 |
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| 作者单位： | [1]武警后勤学院救援医学系药物化学教研室,天津300309 [2]天津市职业与环境危害生物标志物重点实验室,天津300309 [3]95876部队后勤部医院,甘肃张掖734100 [4]武警后勤学院临床医学系解剖学教研室,天津300309 |
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| 摘 要： | 【目的】设计、合成具有扩张冠状动脉活性的新型苯并呋喃衍生物。【方法】在参阅文献的基础上,利用格氏反应等化学方法进行合成,并对未见文献报道的目标化合物进行核磁共振和质谱分析。【结果】合成了11个目标化合物,波谱鉴定及数据分析结果表明,其中有9个为新化合物。【结论】经核磁共振和质谱确认,合成的新化合物与设计的化合物结构一致。
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| 关 键 词： | 苯并呋喃衍生物 结构修饰 有机合成 |
Synthetization of benzofuran derivatives |
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| CUI Ying,TONG Wei,LIN Ming,WANG Peng. Synthetization of benzofuran derivatives[J]. Acta Academiae Medicinae CPAPF, 2014, 0(1): 13-17 |
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| Authors: | CUI Ying TONG Wei LIN Ming WANG Peng |
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| Affiliation: | (Department of College of Rescue Medicine, Medicinal Chemistry, Logistics University of PAPF, Tianjin 300309, China) |
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| Abstract: | 【Objective】To design and synthesize a new type of coronary dilator with structure of benzofuran.【Methods】On the basis of literature, the derivatives were synthesis by Grinard reaction and some other chemical reaction. The structures of target compounds, which haven＇t been reported in literature, were determined by1H-NMR and MS method.【Result】Eleven target compounds were synthesized, nine of which proved as the new compounds with determination and analysis of1H-NMR and MS spectrum.【Conclusion】 With the determination of1H-NMR and MS, it is proved that the structure of new compounds are correspond with that of the designed compounds. |
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| Keywords: | Benzofuran derivatives Structure modification Organic synthesis |
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