SPARC expression and prognostic value in non-small cell lung cancer |
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Authors: | Yan Huang Jing Zhang Yuan-Yuan Zhao Wei Jiang Cong Xue Fei Xu Hong-Yun Zhao Yang Zhang Li-Ping Zhao Zhi-Huang Hu Zhi-Wen Yao Qian-Yong Liu and Li Zhang State |
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Affiliation: | Key Laboratory of Oncology in South China,Guangzhou, Guangdong 510060, P. R. China;2Department of MedicalOncology, Sun Yat-sen University Cancer Center, Guangzhou,Guangdong 510060, P. R. China;3Department of Medical Oncology,Cancer Hospital of Guangxi Medical University & Guangxi AutonomousRegional Cancer Hospital, Nanning, Guangxi 530021, P. R. China;4National Anti-Cancer Drug Clinical Research Center, Sun Yat-senUniversity Cancer Center, Guangzhou, Guangdong 510060, P. R.China;5Abraxis BioScience, Inc., Los Angeles, CA 90025, USA. |
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Abstract: | Secreted protein,acidic and rich in cysteine (SPARC) is expressed in numerous types of tumors and is suggested to have prognostic value.Moreover,because of its strong affinity for albumin,and hence albumin-bound drugs,SPARC has increasingly become a focus for research.In this study,we aimed to determine SPARC expression in patients with non-small cell lung cancer (NSCLC) and investigate the association of SPARC with disease prognosis.Tissue microarrays were constructed with specimens from 105 patients with NSCLC treated at Sun Yat-sen University Cancer Center,and immunohistochemical analysis was performed on these tissue microarrays to assess SPARC expression.Our results showed that SPARC expression status did not significantly relate with age,gender,and tumor stage.However,SPARC was expressed more frequently in squamous cell carcinoma than in adenocarcinoma (75% vs.43.5%,P =0.004).Patients with smoking history had higher SPARC expression than non-smokers (68.2% vs.33.3%,P =0.002).In both univariate and multivariate analyses,SPARC was a prognostic factor of overall survival (HR =0.32; 95% CI:0.16-0.65) but not disease-free survival.Our study indicates that SPARC expression is higher in squamous cell carcinoma than in adenocarcinoma in NSCLC.Most notably,SPARC can be used as a prognostic factor for NSCLC. |
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Keywords: | Non-small cell lung cancer prognosis SPARC |
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