Fetal grafting for Parkinson's disease: Expression of immune markers in two patients with functional fetal nigral implants |
| |
| Institution: | 1. Research Center for Brain Repair and Department of Neurological Sciences, Rush Presbyterian St.-Lukes Medical Center, Chicago, IL 60612, USA;2. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;3. Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;4. Department of Neurology, Mt. Sinai School of Medicine, New York, NY 10029, USA;1. Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children''s Training and Research Hospital, Istanbul, Turkey;2. Pediatric Cardiology, Zeynep Kamil Maternity and Children''s Training and Research Hospital, Istanbul, Turkey;3. Section of Biochemistry, Institute of Cardiology, Istanbul University, Istanbul, Turkey;4. Koc University, School of Medicine, Istanbul, Turkey;1. School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, People’s Republic of China;2. Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, People’s Republic of China;3. Department of Quality Control, The First Affiliated Hospital of Zhejiang University, School of Medcine, Hangzhou, Zhejiang, People’s Republic of China;4. Department of Environmental Health and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Hubei, Wuhan 430030, People’s Republic of China;5. Tianjin Municipal Inspection Bureau for Health And Family Planning, 94 Guizhou Road, Heping District, Tianjin 300070, People’s Republic of China;1. Department of Neurology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China;2. The Institute of Small Vessel Disease of the Nervous System, Peking University, Beijing Key Laboratory, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China;3. The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China |
| |
| Abstract: | In a number of centers throughout the world, fetal nigral transplantation is being performed for the treatment of Parkinson's disease (PD). Clinical results have been inconsistent. One parameter that differs among transplant studies is the degree and manner by which patients are immunosuppressed following transplantation. Indeed, the role of the immune system following fetal grafting in humans is not well understood. Recently, two patients from our open label trial that received fetal nigral implants have come to autopsy. These patients were immunosuppressed with cyclosporin for 6 mo posttransplantation and survived for a total of 18 mo postgrafting. Robust survival of grafted dopamine-containing cells was observed in both cases. Immunostaining for HLA-DR revealed a dense collection of cells within grafts from both cases. HLA-DR staining was rarely observed within the host including nongrafted regions of the striatum. A more detailed analysis of immune markers was performed in Case 2. Numerous pan macrophages, T-cells, and B-cells were observed within graft sites located in the postcommissural putamen. In contrast, staining for these immune cells was not observed within the ungrafted anterior putamen. These findings suggest that even in healthy appearing functional nigral implants, grafts are invaded by host immune cells that could compromise their long-term viability and function. Alternatively, immune cells are known to secrete trophic factors, which may ultimately favor graft survival and function. Further work is needed to understand the role of the immune system in fetal grafting. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
