非瓣膜性心房颤动患者血浆纤维蛋白原水平与缺血性卒中的关系

目的:探讨血浆纤维蛋白原水平增高是否为非瓣膜性心房颤动(NVAF)患者心源性栓塞的独立预测因素.方法:对因心脏原因住院的98例NVAF患者进行评价,其中24例患者有缺血性卒中病史.分析空腹血浆纤维蛋白原水平与缺血性卒中之间的关系.结果:在校正传统心血管危险因素后,与无缺血性病史者相比,具有缺血性卒中病史的NVAF患者的年龄显著更大(73.6岁±8.4岁对69.1岁±10.3岁,P=0.017),高血压患病率显著更高(83.3%对66.2%,P=0.011),左心室收缩功能障碍的患者比例显著更高(63.1%对45.9%,P=0.006),血浆纤维蛋白原水平显著增高(365 mg/dL±108 mg/dL对12 mg/dL±82 mg/dL,P=0.008).结论:在因心脏原因住院的老年NVAF患者中,血浆纤维蛋白原水平与缺血性卒中病史独立相关.

Relationship Between Plasma Fibrinogen Level and Ischemic Stroke in Patients with Nonvalvular Atrial Fibrillation

Objective:To investigate whether the increased plasma fibrinogen level is an independent predictor of cardiogenic embolism in patients with nonvalvular atrial fibrillation (NVAF).Methods:Ninety-eight patients with NVAF hospitalized for cardiac causes were evaluated,and 24 of them had a history of ischemic stroke.The relationship between fasting plasma fibrinogen level and ischemic stroke were analyzed.Results:After adjusting traditional cardiovascular risk factors.the patients with NVAF who had the history of ischemic stroke were significantly older than those without(mean [SD] age 73.6 [8.4]vs.69.1[10.3] years,P=0.017).1he prevalence of hypertension was significantly higher(83.3%va.66.2%,P=0.011).The proportion of patients with left ventricular systolic dysfunction was significantly higher(63.1% vs.45.9%,P=0.006),and plasma fibrinogen level increased significantly (mean [SD] 365 [108]vs.312[82] mg/dL,P=0.008).Conclusions:Plasma fibrinogen level is independently associated with a history of ischemic stroke in older patients with NVAF hospitalized for cardiac causes.