维吾尔族、汉族慢性胃炎患者中HLA-DRB1*12等位基因与幽门螺杆菌感染的关系

目的：探讨慢性胃炎患者HLA-DRB1＊12等位基因与幽门螺杆菌（Hp）感染的关系.方法： 采用Hp分离培养技术检测36例汉族、33例维吾尔族慢性胃炎患者的Hp感染情况,并采用聚合酶链反应-序列特异性引物（PCR-SSP）方法检测HLA-DRB1＊12等位基因多态性.结果： 汉族、维吾尔族慢性胃炎患者Hp阳性率分别为56%、79%,维吾尔族明显高于汉族（P＜0.05）;维吾尔族与汉族慢性胃炎患者Hp（-）者的HLA-DRB1＊12等位基因检出率高于Hp（＋）者,但差异无统计学意义（P＞0.05）.结论： 维吾尔族慢性胃炎患者Hp阳性率可能高于汉族,维吾尔族与汉族慢性胃炎患者中HLA-DRB1＊12等位基因可能与Hp感染无关.

The association of the helicobacter pylori infection and HLA-DRB1 alleles in Uygur ethnic in Xinjiang

Objective: To compare the prevalence of H.pylori infection in gastritis of Xinjiang Uygur, Han ethnic groups, and to analyze the association of HLA-DRB1*12 allele of these two ethnic groups gastritis with H.pylori infection. Methods: Diagnosis by H.pylori culture from gastric mucous for 36 Han and 33 Uygur chronic gastritis. Polymorase chain reaction single strand polymorphism (PCR-SSP) technique was applied to determine the polymorphism of the HLA-DRB1*12 locus of these groups and then the association of HLA-DRB1*12 allele of these groups with H.pylori infection was analyzed by SPSS software. Results: The prevalence of H.pylori infection was 56% in Han patients which was lower than that in Uygur patients (79%), (P<0.05). The distribution of HLA-DRB1*12 locus was not significantly different between the 2 groups. The frequency of HLA-DRB1 *12 allele was higher in person without H.pylori infection (P>0.05). Conclusions: The results indicated that the prevalence of H.pylori infection in Uygur was higher than in Han ethnic group.HLA-DRB1*12 allele have no relationship with H.pylori infection.