清代抄本《毓麟验方》中医药治疗男女不育不孕病用药思路探析

目的:基于数据挖掘清代佚人所撰《毓麟验方》中医药治疗男女不育不孕病用药配伍思路的文献研究。方法:将清代佚人所撰《毓麟验方》治疗男女不育不孕病的中医复方方药录入计算机,建立数据库,运用统计学方法分析其用药配伍规律。结果:整理中药复方117首中药内服复方,涉及199味中药,用药总次数964次;高频次核心药以麝香、丁香、附子、肉桂、蛇床子、川椒、蟾酥、淫羊藿等为主;药类以补虚药、温里药、开窍药、收涩药等为主;药味以辛、甘、苦为主,累计频率达80.68%;药性以温、平、寒为主,累计频率达87.87%;归经以肾、脾、肝、心、肺、胃为主,累计频率91.39%。结论:该古籍临证选用高频次麝香、丁香、附子、肉桂、蛇床子、川椒、蟾酥、淫羊藿加减处方用药;突显以温里药和补阳药相参加减治疗男女不育不孕证的用药特点。

Chinese Medicine Treatment of Male and Female Infertility in Qing Dynasty Yulin Recipe Ropy

Objective: To investigate the studies and ideas on traditional Chinese medicine treatment for male and female infertility based on data mining in Qing dynasty Yulin Recipe Ropy. Method: The Chinese medicine compound recipes for male and female infertility in Qing Dynasty Yulin Recipe Ropy were input to the computer for establishment of a database, and then statistical methods were used to analyze the rule of medication. Result: Totally 117 compound Chinese medicine recipes involving 199 herbs and 964 medication times were collected;core herbs with high-frequency mainly included Moschus, Caryophylli Flos, Aconiti Lateralis Radix Praeparata, Cinnamomi Cortex, Cnidii Fructus, Pericarpium zanthoxyli, Bufonis Venenum, Epimedii Folium. The drugs mainly included the tonic drugs, interior-warming drugs, resuscitation-inducing drugs, and astringent drugs;the herbs with pungent, sweet, and bitter flavors had a cumulative frequency of 80.68%, the herbs with main nature of warming, flatness and coldness had a cumulative frequency of 87.87%, the herbs returning to kidney, spleen, liver, heart, lung, and stomach had a cumulative frequency of 91.39%. Conclusion: Moschus, Caryophylli Flos, Aconiti Lateralis Radix Praeparata, Cinnamomi Cortex, Cnidii Fructus, Pericarpium zanthoxyli, Bufonis Venenum, Epimedii Folium were used with high-frequency in clinical use as recorded in the ancient book;addition and reduction of warming drug and Yang supplementing drug were regarded as the medication characteristics for male and female infertility syndrome.