心律失常患者血清内源性洋地黄样因子浓度变化的初步观察

用放射免疫方法测定43例心律失常患者、40例非心律失常心脏病患者和40例正常人血清内源性洋地黄样因子(EDF)浓度,结果发现:室性早搏(VPB)患者血清EDF浓度明显高于正常(P<0.05),快速心房纤颤(Af)患者血清EDF浓度明显低于正常(P<0.001),房性早搏(APB)患者血清EDF浓度虽低于正常,但差异无显著性(P>0.05),非心律失常心脏病患者血清EDF浓度与正常人无显著性差异(P>0.05)。随心律失常得以控制或改善后,VPB患者血清EDF水平明显下降(P<0.05),而Af患者血清EDF浓度明显回升(P<0.01)。提示心律失常与血清EDF水平有一定关系。

The Preliminary Observation of Changes of Serum Endogenous Digitalis-like Factor Concentration In Patients With Arrhythmia

The serum endogenous digitalis-like factor (EDF) concentration was determined by radio immunoassay in 43 patients with arrhythmia, in 40 patients with heart diseases but without arrhythmia, and in 40 normal cases. The results showed that serum EDF concentration in patients with ventricular premature beats (VPB) was markedly higher than that of normal cases (P<0.05); in patients with rapid atrial fibrillation (Af) was markedly lower than that of normal cases (P<0.001); in patients with atrial premature beats (APB) was slightly lower than that of normal cases, but no significant difference(P>0.05); in patients without arrhythmia was no significant difference with normal cases (P>0.05). The serum EDF concentration in patients with VPB significantly droped (P<0.05) and with atrial fibrillation significantly raised(P<0.01) as arrhythmia was controlled or improved.