| 薄荷醇及冰片对磺胺嘧啶和伊文思蓝在脑中分布的影响 |
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| 引用本文： | 徐伟,王宗锐.薄荷醇及冰片对磺胺嘧啶和伊文思蓝在脑中分布的影响[J].中药药理与临床,1995,11(6):31-33. |
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| 作者姓名： | 徐伟 王宗锐 |
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| 作者单位： | 广东医学院药理教研室 |
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| 摘 要： | 薄荷醇（ｉｇ１０％薄荷醇石蜡油液１５ｍｌ／ｋｇ）及冰片（ｉｇ１０％冰片石蜡油液１５ｍｌ／ｋｇ）可明显延长磺胺嘧啶在大鼠体内分布相半衰期ｔ１／２ａ，增加磺胺嘧啶在大鼠脑内的浓度。薄荷醇、冰片（ｉｇ０．５ｇ／ｋｇ×４ｄ）还可使伊文思蓝透过小鼠血脑屏障， 但其透过量远明显低于夹闭双侧颈动脉再灌注脑损伤组。以上结果提示，薄荷醇、冰片可能具有促进Ｓｕｌ透过血脑屏障，而对血脑屏障结构的损伤可能性小。
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| 关 键 词： | 薄荷醇 冰片 磺胺嘧啶 伊文思蓝 脑中分布 药物代谢动力学 |
Effect of menthol and borned on the distribution of sulfadiazine sodium andEvan's blue in the rat and mouse brain |
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| Xu Wei, Wang Zhongrui.Effect of menthol and borned on the distribution of sulfadiazine sodium andEvan''s blue in the rat and mouse brain[J].Pharmacology and Clinics of Chinese Materia Medica,1995,11(6):31-33. |
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| Authors: | Xu Wei Wang Zhongrui |
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| Abstract: | enthol (1.5g/kg. ig) and Borneol (1.5 g/kg) prolonged the sulfadiazine sodium dise ibution half-life t1/2a in rats,above dosage of menthol and borned given orally also increased the cocentration of sulfadiazine sodium in the ratbrain. Menthol (ig 0. 5/g/kg for 3 days) and borned (ig 0. 5 g/kg for 3 days) promoted the concentration ofEvan's blue in the mouse brain, but the value of concentration was significantly lower than mice suffered from the ischemia-reperfusion injury. The resultS suggested that the menthol and borned could enhanced the sulfadiazine sodiumtransffertation in brain-blood barier with no damage to brain-blood barier. |
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| Keywords: | menthol borned sulfadiazine sodium Evan's blue brain-blood barier pharmacokinetics |
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