| RP-HPLC法测定罗氟司特片的溶出度 |
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| 引用本文： | 孟咏梅,吴标,柳郁.RP-HPLC法测定罗氟司特片的溶出度[J].北方药学,2015(2):2-3. |
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| 作者姓名： | 孟咏梅 吴标 柳郁 |
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| 作者单位： | 安徽省皖北药业股份有限公司 宿州 234000;合肥久诺医药科技有限公司 合肥 230088 |
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| 摘 要： | 目的：建立罗氟司特片溶出度的反相高效液相色谱法测定方法。方法：采用C18色谱柱（150mm×4.6mm，5.0μm），以水∶乙腈（35∶65）为流动相，检测波长为215nm，柱温25℃，流速1.0ml/min。结果：罗氟司特溶出度测定的线性回归方程为A=425705C-273.88，r=0.9999，线性范围0.0506～0.9104μg/ml。平均回收率为99.77%，RSD为0.25%。结论：该方法操作简便，精密度高，重复性好，可用于罗氟司特片溶出度的测定。
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| 关 键 词： | RP-HPLC 罗氟司特片 溶出度 |
Determination of dissolution of roflumilast tablets by RP-HPLC |
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| Abstract: | Objective:To establish an RP-HPLC method for determining the dissolution of roflumilast tablets. Methods:Stationary phase was C18 (150mm×4.6mm,5.0μm),with water-acetonitrile (35:65) as the mobile phase. The detection wavelength was 215nm, column temperature was 25℃, and flow rate was 1.0ml/min. Results:The regression equation of roflumilast was A=425705C-273.88,r=0.9999, which was linear over the range of 0.0506~0.9104μg/ml. The average recovery of Dual acylate was 99.77%, and RSD was 0.25%. Conclusion:This method is simple, accurate , repeatable and can be used for the dissolution of roflumilast tablets. |
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| Keywords: | RP-HPLC Roflumilast Dissolution |
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