| 腺苷对大鼠肾脏缺血-再灌注损伤的保护作用 |
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| 引用本文： | 严博泉,刘少青,权昌益,姜佑三.腺苷对大鼠肾脏缺血-再灌注损伤的保护作用[J].中国危重病急救医学,2000,12(4):217-219. |
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| 作者姓名： | 严博泉 刘少青 权昌益 姜佑三 |
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| 作者单位： | 延边大学医学院附属医院泌尿外科,吉林,延边,133000 |
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| 基金项目： | 延边大学医学院硕士研究生课题 |
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| 摘 要： | 目的：探讨腺苷对肾脏缺血－再灌注损伤的保护作用机制。方法：将大鼠随机分为对照组（ＣＯＮ）、缺血－再灌注组（ＩＲ）、给予腺苷后缺血－再灌注组（ＡＤ）。除病理组织学变化外，分别检测各组不同灌注时间Ｎａ－Ｋ－ＡＴＰ酶和Ｃａ＾２＋－ＡＴＰ酶活力的变化。结果：病理组织学肾小管评分，ＡＤ组和ＣＯＮ组均明显低于ＩＲ组，ＡＤ组和ＣＯＮ组之一无显著性差异。Ｎａ－Ｋ－ＡＴＰ酶和Ｃａ＾２＋－ＡＴＰ酶的活性，在ＡＤ组和Ｃ
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| 关 键 词： | 肾脏缺血 腺苷 再灌注损伤 保护机制 |
| 修稿时间： | 2000-01-10 |
Protective effect of adenosine on renal damage in rats after ischemia-reperfusion injury |
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| YAN Boquan,LIU Shaoqing,QUAN Changyi,et al..Protective effect of adenosine on renal damage in rats after ischemia-reperfusion injury[J].Chinese Critical Care Medicine,2000,12(4):217-219. |
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| Authors: | YAN Boquan LIU Shaoqing QUAN Changyi |
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| Institution: | YAN Boquan,LIU Shaoqing,QUAN Changyi,et al.Department of Urology,Affiliated Hospital of Medical College,Yanbian University,Yanji 133000 |
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| Abstract: | Objective:To investigate the protective effect of adenosine on renal damage in rats after ischemiareperfusion injury.Methods:Rats were randomly divided into control group (CON),adenosine treatment group (AD) and ischemiareperfusion group (IR).In different groups,pathological changes and the activity of Na K ATPase as well as Ca 2 ATPase were determined at various intervals.Results:Pathological scores of renal tubules in AD and CON were lower than that in IR ( P <0 05 or P <0 01),but they were similar between AD and CON (all P >0 05).No marked difference in Na K ATPase and Ca 2 ATPase activities was observed between AD and CON(all P >0 05),while ATPasese activities in two groups were significantly higher than that in IR(all P <0 01).Conclusions:Adenosine could protect against the damage of renal ischemiareperfusion,which may be related to the improvement of energy metabolism. |
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| Keywords: | kidney adenosine ischemiareperfusion protective effect |
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