乙型病毒性肝炎与肝癌关系的流行病学研究

本文综合扶绥等地10多年来进行乙型病毒性肝炎与肝癌关系的系列流行病学研究结果:(1)肝癌高低发区HBsAg对比调查,凡采用灵敏性较差的检测方法,往往有不平行关系;若采用灵敏性高的RIA法,无论成人或儿童都表现出明显的平行关系.(2)反复、多次肝癌户与非肝癌户家庭成员的HBsAg检测及病例(对照)研究、前瞻性研究都一致证明乙型肝炎与肝癌有非常密切的关系.病例对照研究最高的OR值达21倍,前瞻性研究最高的RR为44.03倍.(3)两次前瞻性研究结合HBV感染,黄曲霉毒素的调查分析;认为扶绥县肝癌高发,HBV感染是一重要因素,但不是唯一的因素,明显的表示与黄曲霉毒素摄入有相互的协同作用.

EPIDEMIOLOGICAL STUDY OF THE RELATIONSHIP BETWEEN HEPATITIS B VIRUS AND PRIMARY HEPATOCELLULAR CARCINOMA

This report is a brief review of a series studies on the relationship between Hepatitis B Virus and liver cancer performed in Fusui county and some other areas in the past ten more years.Our data showed: 1.The PHC rates were correlative to the HBsAg prevalence rates, if the HBsAg was tested in RIA.although they might be not correlative if it was tested in other methods not sensitive enough. 2.Studies of PHC clustering families and case-control studies, prospective studies showed that PHC was highly associated with hepatitis B.with the OR of 2.1 in one of the case control studies and RR of ,44.03 in the prospective study. 3.Two prospective studies, put the HBV infection and aflatoxin (AFT) as the factors of survey, showed that HBV was one important, but not the sole factor, which could cause PHC.It was obvious that the AFT was a coordinator of HBV to cause PHC in studies area.