肾病综合征患者血浆脂蛋白(a)水平与部分纤溶指标活性的关系

目的研究肾病综合征患者血浆脂蛋白(a)与部分纤溶指标活性的关系。方法应用酶联免疫吸附试验(ELISA)分别测定60例肾病综合征患者及51名健康对照者的血浆脂蛋白(a)浓度,并以底物显色法测定其组织型纤溶酶原激活剂(tPA)及其抑制物(PAI)活性。结果肾病综合征患者血浆脂蛋白(a)浓度和PAI活性明显升高,tPA活性明显降低;脂蛋白(a)浓度与血浆尿素氮水平、PAI活性均呈正相关;脂蛋白(a)浓度与tPA活性呈负相关。结论肾功能对血浆脂蛋白(a)浓度起一定的调节作用,脂蛋白(a)水平的升高与纤溶活性低下有关。

Relationship between plasma lipoprotein(a) level and some indexes of fibrinolytic activity in patients with nephrotic syndrome

Objective To study the relationship between plasma lipoprotein(a) level and fibrinolytic activity in patients with nephrotic syndrome. Methods Plasma lipoprotein(a) was determined by enzyme-linked immunosorbent assay(ELISA) in 60 patients with nephrotic syndrome and 51 healthy subjects.Plasma activity of tissue type plasminogen activator(tPA) and plasminogen activator inhibitor(PAI) were determined by spectrophotometry. Results Plasma lipoprotein(a) level and activity of PAI in nephrotic syndrome patients were significantly higher than the control group,however plasma activity of tPA in nephrotic syndrome patients was significantly lower.Plasma lipoprotein(a) level was significantly correlated with plasma urea nitragen(BUN) level and activity of PAI and was negatively correlated with activity of tPA. Conclusions The renal function may regulate the plasma lipoprotein(a) level and elevation of lipoprotein(a) level may be related with fibrinolytic activation.