| miR -542-5p 在浆液性卵巢癌中的表达及意义 |
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| 引用本文： | 陈琳,;姚丽,;张佳瑞,;任拼,;王姝妹,;兰淼,;张伟,;李艳红.miR -542-5p 在浆液性卵巢癌中的表达及意义[J].现代肿瘤医学,2014(8):1936-1939. |
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| 作者姓名： | 陈琳 ;姚丽 ;张佳瑞 ;任拼 ;王姝妹 ;兰淼 ;张伟 ;李艳红 |
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| 作者单位： | [1]第四军医大学唐都医院妇产科,陕西西安710038; [2]第四军医大学唐都医院病理科,陕西西安710038 |
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| 基金项目： | 陕西省科技攻关课题资助项目（编号：2007K09-09） |
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| 摘 要： | 目的：检测 miR -542-5p 在浆液性卵巢癌中的表达，并分析 miR -542-5p 的表达与浆液性卵巢癌临床病理特征之间的关系，探讨其意义。方法：采用实时荧光定量 PCR 技术分析100例浆液性卵巢癌组织及50例正常输卵管伞端组织中 miR -542-5p 的表达。结果：浆液性卵巢癌组织中 miR -542-5p 的表达显著低于正常输卵管伞端组织（P ﹤0.05）。miR -542-5p 的表达与浆液性卵巢癌各临床病理特征之间差异均无统计学意义（P ﹥0.05）。结论：miR -542-5p 可能作为抑癌基因参与了浆液性卵巢癌的发生，对于卵巢癌的早期诊断及治疗具有潜在意义。
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| 关 键 词： | 浆液性卵巢癌 miRNA miR-542—5p 实时荧光定量PCR |
The expression and significance of miR - 542 - 5p in serous ovarian cancer |
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| Institution: | Chen Lin, Yao Li, Zhang Jiarui, Ren Pin, Wang Shumei, Lan Miao, Zhang Wei, Li Yanhong( 1 Department of Obstetrics and Gynecology; 2Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Shaanxi Xi＇an 710038, China) |
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| Abstract: | To detect the expression of miR - 542 - 5p in serous ovarian cancer,and analyze the corre-lation of its expression with clinicpathological features,investigate the significance in carcinogenesis and development. Methods：Using quantitative real - time PCR to assess the expression of miR - 542 - 5p in 100 serous ovarian cancer tissues and 50 normal fimbriated end of the distal fallopian tissues. Results：The expression of miR - 542 - 5p in se-rous ovarian cancer tissues was significantly lower than in normal fimbriated of the distal fallopian tissues（P ﹤ 0. 05）. There was no difference for miR - 542 - 5p expression with clinicopathological features in serous ovarian cancer（P ﹥0. 05）. Conclusion：miR - 542 - 5p may participate the origination of serous ovarian cancer as a tumor - suppressor, and it has potential significance for the early diagnosis and treatment of ovarian cancer. |
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| Keywords: | serous ovarian cancer miRNA miR - 542 - 5 p RT - PCR |
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