三维适形放疗联合EP方案治疗晚期胸腺癌的疗效观察

目的:观察三维适形放疗联合EP方案治疗晚期胸腺癌的治疗效果。方法:分析我院50例经病理细胞学确诊的晚期胸腺癌患者的临床资料，将患者按照不同治疗方法分为三组，A组17例，采用三维适形放疗同期联合EP方案；B组18例，采用EP方案两周期后贯续三维适形放疗；C组15例，采用单纯三维适形放疗的方法。结果:三组局部控制率分别为88.2%、66.7%、46.7%,A组显著高于B、C 组,B组显著高于C组。A、B两组均无明显化疗毒副反应发生，放射性损伤发生率无显著差异。疾病控制率分别为94.1％、77.8％、53.3％，三组比较差异均有统计学意义（P<0.05）。结论:对晚期胸腺癌采用三维适形放疗同期联合EP方案的治疗效果优于单纯三维适形放疗及序贯放化疗，且毒副反应可耐受,可以控制肿瘤，减少复发。

Efficacy of three - dimensional conformal radiotherapy combined with EP regimen in the treatment of advanced invasive thymoma

To observe the effect of three - dimensional conformal radiotherapy in combination with EP regimen for treatment on advanced thymic carcinoma. Methods：To analyze the clinical data of 50 patients with ada-nced thymic carinoma. All patients were divided into three groups：group A 17 cases,to use three - dimensional con-formal radiotherapy combined EP regimen;group B 18 cases after two cycles of EP regimen used consistently contin-ued dimensional conformal radiotherapy;group C 15 cases,only use three - dimensional conformal radiotherapy. Re-sults：Local control rates of three groups were 88. 2% ,66. 7% ,46. 7% ,group A was significantly higher than B,C;group B was significantly higher than group C. In group A,B there were no significant side effects of chemotherapy,ra-dioactive injury rate was no significant difference. Disease control rates were 94. 1% ,77. 8% and 53. 3% in three groups,the difference was statistically significant（P ﹤ 0. 05）. Conclusion：Advanced thymic carcinoma treated by three dimensional conformal radiotherapy combined EP regimen over the same period its therapeutic effect was better than simple sequential three - dimensional conformal radiotherapy and chemotherapy.