首页 | 本学科首页   官方微博 | 高级检索  
     

视网膜母细胞瘤组织浸润程度临床相关危险因素研究
引用本文:高蕊,李彬,喻巍,孙宪丽,李辽青,任若瑾,高飞. 视网膜母细胞瘤组织浸润程度临床相关危险因素研究[J]. 眼科, 2006, 15(6): 389-391
作者姓名:高蕊  李彬  喻巍  孙宪丽  李辽青  任若瑾  高飞
作者单位:100005,首都医科大学附属北京同仁医院眼科中心北京市眼科研究所
摘    要:
目的探讨视网膜母细胞瘤(Rb)对眼球组织浸润侵犯程度的相关临床危险因素。设计回顾性病例系列。研究对象经组织病理学确诊的Rb患者394例。方法收集1990-2005年北京同仁医院较完整的394例Rb患者的临床病理资料,术前观察主要临床体征,术后光镜下判读Rb眼球各组织浸润程度,通过logistic多元回归分析Rb眼球组织浸润程度的临床危险因素。主要指标Rb各临床体征与眼球组织浸润程度及两者之间的相关性。结果394例Rb中侵犯视盘315例(79.7%),侵犯筛板纤维203例(51.4%),肿瘤穿过筛板至球后视神经内102例(25.8%),侵犯脉络膜102例(25.8%),视神经切除断端受累者26例(6.6%)。统计分析显示:脉络膜组织受累与病程(P=0.032)、结膜充血(P=0.023)、眼球突出(P=0.026)及继发青光眼(P=0.027)有关;视神经切除断端浸润与结膜充血(P=0.008)、虹膜新生血管形成(P=0.033)、眼球突出(P=0.000)有关。结论本组Rb视神经侵犯率较高。病程长、结膜充血、眼球突出是眼球组织侵犯的主要因素。

关 键 词:视网膜母细胞瘤  组织浸润  临床危险因素
收稿时间:2006-09-01
修稿时间:2006-09-01

Study on the relative clinical risk factors for histopathological evidence of invasion in retinoblastoma
GAO Rui,LI Bin,YU Wei,SUN Xian-li,LI Liao-qing,Ren Ruo-jin,GAO Fei. Study on the relative clinical risk factors for histopathological evidence of invasion in retinoblastoma[J]. Ophthalmology in China, 2006, 15(6): 389-391
Authors:GAO Rui  LI Bin  YU Wei  SUN Xian-li  LI Liao-qing  Ren Ruo-jin  GAO Fei
Affiliation:Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Affiliated Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China
Abstract:
Objective To study the relative clinical risk factors of retinoblastoma for predicting histopathologic invasion degree. Design Retrospective observational case series. Participants 394 patients with retinoblastoma confirmed by histopathology. Methods A retrospective study on the relationship between the clinical features and histopathological invasion was performed in 394 patients with retinoblastoma treated by enucleation between 1990~2005. Observe the preoperative clinical signs and examine the histopathological invasion degree under microscope. The logistic regression model was used for multivariate analysis. Main Outcome Measures The clinical features and histopathological invasion degree and the relativity between them. Results There were 315 cases(79.7%)with optic nerve invasion. The choroid invasion rate was 25.8%. The invasion was up to the cut end of the optic nerve in 26 eyes (6.6%).The choroid invasion related to course of disease (P=0.032), conjunctival congestion (P=0.023), exophthalmos (P=0.026)and secondary glaucoma(P=0.027). The invasion up to the optic nerve line related to conjunctival congestion(P=0.008)and iris neovascularization(P= 0.033 )and exophthalmos (P=0.000). Conclusion The incidence of optic nerve invasion is high in patients of this study. Long course of disease, conjunctival congestion and exophthalmos are the main risk factors for eyeball invasion due to retinobalstoma.
Keywords:retinoblastoma  histopathologic invasion  clinical risk factor
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号