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烟酸凝胶骨架缓释片的稳定性考察
引用本文:国玉芝,张志国,候大平,田寅. 烟酸凝胶骨架缓释片的稳定性考察[J]. 中国药师, 2008, 11(11)
作者姓名:国玉芝  张志国  候大平  田寅
作者单位:佳木斯大学第一附属医院药剂科,黑龙江,佳木斯,154002
摘    要:
目的:考察烟酸凝胶骨架缓释片贮存期间稳定性。方法:采用加速试验和长期试验方法,考察外观性状、含量和释放度。结果:密封包装条件下,36个月内外观性状、含量和释放度检查结果没有显著性变化。结论:该制剂密封条件下贮存,有效期可以定为2年。

关 键 词:烟酸  缓释片  稳定性

Study On Stability of Nicotinic Acid Gel Matrix Sustained Release Tablets
Guo Yuzhi,Zhang Zhiguo,Hou Daping,Tian Yin. Study On Stability of Nicotinic Acid Gel Matrix Sustained Release Tablets[J]. China Pharmacist, 2008, 11(11)
Authors:Guo Yuzhi  Zhang Zhiguo  Hou Daping  Tian Yin
Affiliation:Guo Yuzhi Zhang Zhiguo Hou Daping Tian Yin (Department of Pharmacy,Affiliated First Hospital of Jiamusi University,Heilongjiang,Jiamusi 154002,China)
Abstract:
Objective:To investigate the stability of gel matrix sustained release tablets of nicotinic acid in storied terms.Method: The characters,content and release rate were studied by the accelerated and long-term tests.Result:Under the tight packing condition, no obvious changes were observed for the characters,contents and release rate of the samples within 36 months.Conclusion:Storied in tight container,the recommended validity life of tablets is 2 years.
Keywords:Nicotinic acid  Sustained release tablets  Stability  
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