BMP 1和mTLL1在牙齿发育中的研究进展

骨形态发生蛋白1(bone morphogenetic protein 1,BMP1)和哺乳动物tolloid样1(mammalian tolloid-like 1,mTLL1)是细胞外基质金属蛋白酶,同属于虾红素家族(astacin family),在包括牙在内的多种组织中共表达.BMP1和mTLL1具有功能冗余性,...

Research progress of bone morphogenetic protein 1 and mammalian tolloid-like 1 in tooth development

Bone morphogenetic protein 1 (BMP1) and mammalian tolloid like 1(mTLL1), members of astacin family, are extracellular matrix metalloproteinases that are co expressed in various tissues including teeth. BMP1 and mTLL1 are functionally redundant, playing an important role in cutting and activating extracellular matrix (ECM) proteins. They regulate ECM deposition by hydrolyzing and pruning precursors of various ECM proteins. Previous studies have shown that BMP1 and mTLL1 play an important role in tooth development through promoting the differentiation of odontoblasts and osteoblast, as well as maintaining the balance of collagen and non collagen proteins in ECM. The research progress of BMP1 and mTLL1 in tooth development is reviewed in this paper.