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| 异丙嗪对小鼠利多卡因致惊厥作用的影响 | |
| 引用本文： | 纪月珑,孟尹,朱颖君,刘亚君,何珂,戴体俊. 异丙嗪对小鼠利多卡因致惊厥作用的影响[J]. 药学与临床研究, 2010, 18(5): 438-439 |
| 作者姓名： | 纪月珑 孟尹 朱颖君 刘亚君 何珂 戴体俊 |
| 作者单位： | 1. 徐州医学院,麻醉学院2006级灌注班,徐州,221004 2. 徐州医学院,研究生部,徐州,221004 3. 徐州医学院,临床医学一系,徐州,221004 4. 徐州医学院,麻醉药理学教研室,徐州,221004 |
| 基金项目： | 国家自然科学基金资助项目,江苏省自然科学基金资助项目 |
| 摘 要： | 目的:观察异丙嗪(promethazine,Prom )对小鼠利多卡因(lidocaine)致惊厥作用的影响.方法:腹腔注射利多卡因建立小鼠惊厥模型,观察腹腔注射3种剂量的异丙嗪对小鼠惊厥持续期、惊厥发生率和死亡率的影响.结果:异丙嗪可剂量依赖性地缩短小鼠利多卡因中毒惊厥的持续期(P＜0.01),但对惊厥发生率、死亡率无显著影响(P＞0.05).结论:异丙嗪缩短利多卡因惊厥持续期,有一定的抗惊厥作用. |
| 关 键 词： | 异丙嗪 利多卡因 药物惊厥 小鼠 |
| 修稿时间： | 2010-05-23 |
Effect of Promethazine on Convulsion Function Caused by Lidocaine in Mice |
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| JI Yue-long,MENG Yin,ZHU Ying-jun,LIU Ya-jun,HE Ke and DAI Ti-jun. Effect of Promethazine on Convulsion Function Caused by Lidocaine in Mice[J]. Pharmacertical and Clinical Research, 2010, 18(5): 438-439 | |
| Authors: | JI Yue-long MENG Yin ZHU Ying-jun LIU Ya-jun HE Ke DAI Ti-jun |
| Affiliation: | Department of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China;Department of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China;Department of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China;Division of Graduate, Xuzhou Medical College, Xuzhou 221002, China;First Clinical Department, Xuzhou Medical College, Xuzhou 221002, China;Department of Anesthetic Pharmacology, Xuzhou Medical College, Xuzhou 221002, China |
| Abstract: | |
| Keywords: | Promethazine Lidocaine Drug seizures Mice |
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