| THE INHIBITORY EFFECT OF ASTRAGALUS MEMBRANACEUS ON COXSACKIE B-3 VIRUS RNA REPLICATION |
| |
| 引用本文： | 彭天庆 杨英珍 HelgaRiesemann ReinhardKandolf. THE INHIBITORY EFFECT OF ASTRAGALUS MEMBRANACEUS ON COXSACKIE B-3 VIRUS RNA REPLICATION[J]. 中国医学科学杂志(英文版), 1995, 10(3): 146-150 |
| |
| 作者姓名： | 彭天庆 杨英珍 HelgaRiesemann ReinhardKandolf |
| |
| 作者单位： | [1]DepartmentofVirology,Max-Planck-InstituteforBio-chemistry,D-82152Martinsrled,Munich,Germany [2]DepartmentofVirology,Max-Planck-InstituteforBio-chemistry,D-82152Martinsrled,Munich,Germany |
| |
| 摘 要： | ![]()
Using mice infected with coxsackie B-3 virus (CVB3) as a viral myocarditis model,we observed the inhibitory effect of Astragalus membranaceus (AM) on CVB3-RNA replication in myocardial tissue of mice by RNA-RNA in situ hybridization with negative-strand RNA probes labelled with ^35S and quantitative imaging analysis of positive signals.The mechanism of its effect on CVB3-RNA replication has been inves-tigated by detection of beta-interferon (β-IFN) as well.Results showed that the copy numbers of CVB3-RNA as well as the histologic scores (necrosis) in myocardial tissues of infected-AM treated mice were sig-nificantly lower than those in infected and normal saline treated mice,suggesting that AM could inhibit the replication of CVB3-RNA,but its effect on CVB3-RNA replication had no correlation with induction of β-IFN.
|
| 关 键 词： | 膜荚黄芪 柯萨病毒 病毒复制 药理作用 β-IFN 动物实验 |
THE INHIBITORY EFFECT OF ASTRAGALUS MEMBRANACEUS ON COXSACKIE B-3 VIRUS RNA REPLICATION |
| |
| Peng Tianqing,Yang Yingzhen,Helga Riesemann and Reinhard Kandolf. THE INHIBITORY EFFECT OF ASTRAGALUS MEMBRANACEUS ON COXSACKIE B-3 VIRUS RNA REPLICATION[J]. Chinese medical sciences journal, 1995, 10(3): 146-150 |
| |
| Authors: | Peng Tianqing Yang Yingzhen Helga Riesemann Reinhard Kandolf |
| |
| Abstract: | ![]()
|
| |
| Keywords: | astragalus membranaeus CVB3-RNA in situ hybridization |
| 本文献已被 CNKI 维普 等数据库收录！ |
