| Triptolide inhibits IL-12 production and T cell-stimulatory capacity of dendritic cells |
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| 作者姓名： | QIU YAN LIU TAO YONG CHEN HUA BIAO CHEN NAN LI MING HUI ZHANG PENG CHENG MA and XUE TAO CAO Institute of Immunology Zhejiang University Hangzhou P.R.China Institute of Immunology Second Military Medical University Shanghai P.R.China Institute of Dermatology Chinese Academy of Medical Sciences Nanjing P.R.China |
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| 作者单位： | QIU YAN LIU 1，2，TAO YONG CHEN 2，HUA BIAO CHEN 2，NAN LI 2，MING HUI ZHANG 2，PENG CHENG MA 3 and XUE TAO CAO 1，2 1 Institute of Immunology，Zhejiang University，Hangzhou，P.R.China 2 Institute of Immunology，Second Military Medical University，Shanghai，P.R.China 3 Institute of Dermatology，Chinese Academy of Medical Sciences，Nanjing，P.R.China |
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| 摘 要： | Extracts of Tripterygium wilfordii Hook F.(TWHF ) are effective in traditional Chinesemedicine for treatment of autoimmune diseasessuch as rheumatoid arthritis, systemic lupus ery thematosus, nephritis and asthma 1, 2]. Trip tolide, a diterpenoid triepoxide, is derived fromTWHF and is responsible for most of the immuno suppressive and anti inflammatory effects ofTWHF. Triptolide has been shown to be effectivein the treatment of autoimmune diseases, …
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| 关 键 词： | IL-12 T细胞 树状细胞 生物学活性 自身免疫性疾病 |
Triptolide inhibits IL-12 production and T cell-stimulatory capacity of dendritic cells |
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| QIU YAN LIU ,,TAO YONG CHEN ,HUA BIAO CHEN ,NAN LI ,MING HUI ZHANG ,PENG CHENG MA and XUE TAO CAO , Institute of Immunology,Zhejiang University,Hangzhou,P.R.China Institute of Immunology,Second Military Medical University,Shanghai,P.R.China Institute of Dermatology,Chinese Academy of Medical Sciences,Nanjing,P.R.China.Triptolide inhibits IL-12 production and T cell-stimulatory capacity of dendritic cells[J].Chinese Journal of Microbiology and Immunology,2005,3(1):66-72. |
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| Authors: | QIUYANLIU TAOYONGCHEN HUABIAOCHEN NANLI MINGHUIZHANG PENGCHENGMA XUETAOCAO |
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| Abstract: | Triptolide is a natural, biologically active component derived from Chinese herb Tripterygium Wilfordii Hook F. (TWHF) which is effective in the clinical treatment of autoimmune diseases, however, the mechanisms by which triptolide exerts immunosuppression remain fully understood. The primary of this study is to demonstrate whether triptolide can affect phenotype, cytokine production and allogeneic T cell-stimulatory capacity of dendritic cells (DCs) which are critical in the induction of immune response or tolerance. Phenotypic analysis show that triptolide does not affect the expression of MHC (Ia b), CD80, CD86 and CD40 of DC stimulated with or not LPS, but significantly inhibits IL-12p70 production by DC in a dose-dependent manner. Triptolide-treated DCs exhibit a reduced capacity to stimulate proliferation of allogeneic CD4 + T lymphocytes. Therefore, triptolide-mediated immunosuppression may due, in part, to the inhibition of IL-12p70 production and impairment of allogeneic T cell-stimulatory capacity of DCs. Our results may provide a possible mechanistic explanation for the effectiveness of triptolide in the treatment of autoimmune diseases. |
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| Keywords: | Triptolide Dendritic cells Interleukin-12 T cell Immunosuppression |
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