温经化瘀合剂药效学研究

目的：观察温经化瘀合剂(当归、川芎、香附、益母草等)治疗痛经、月经不调等作用。方法：对小鼠子宫、卵巢进行重量测定，二甲苯致小鼠耳肿胀法，缩宫素诱发大鼠痛经模型和前列腺素E1诱发小鼠痛经模型法，对大鼠离体子宫收缩活动的影响。结果：温经化瘀合剂能明显增加小鼠子宫重量，减轻二甲苯引起的小鼠耳肿胀度，减少缩宫素所致大鼠扭体反应次数和前列腺素E1所致小鼠扭体反应次数，既能使正常大鼠离体子宫收缩，又能对抗缩宫素对大鼠离体子宫的收缩作用。结论：温经化瘀合剂具有镇痛、抗炎作用，对子宫有双向调节作用。

Study on pharmacodynamics of Wenjinghuayu Mixture

Objective: To observe the therapeutic actions of Wenjinghuayu Mixture(Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Cyperi, Herba Leonur, etc.) on dysmenorrhea and irregular menstruation. Methods: The uterus and ovary of mice were weighted. The ear edema and writhing and isolated rat uterus were used for experiment models. Results: Wenjinghuayu Mixture could significantly increased the weight of uterus of mice. It had inhibitory effects on mice ear edema and could reduce the writhing of mice and rats. It had biphasic effect on rat's isolated uterine contraction. Conclusion: Wenjinghuayu Mixture has effects of analgesia and anti-inflammation and has biphasic effect on uterine contraction.